NEURO

The expression of the CREB gene may function as a switch to regulate fear and extinction learning. The findings could provide a new avenue of treatment for PTSD and other mental health disorders. from Neuroscience News https://ift.tt/3mKbRBb

Using brain tissue samples, researchers have identified a new epigenetic clock for brain aging. The study reveals how the epigenetic clock could provide insight into accelerated brain aging and neurodegenerative disorders. from Neuroscience News https://ift.tt/3eeoXU1

The risk of stroke is 54% higher in those who experience symptoms of depression, a news study reports. from Neuroscience News https://ift.tt/3oHyQhT

Researchers explore the "sociocultural mental health phenomena" of Hikikomori, a disorder in which people socially isolate for extended periods of time. from Neuroscience News https://ift.tt/34Lxta2

Study reveals a key role for the ventromedial hypothalamus in fight or flight behaviors. Findings suggest the ventromedial hypothalamus alters in response to social experiences. from Neuroscience News https://ift.tt/3mIafrI

In order to better educate patients, predictive models have been implemented to stratify surgical risk, thereby instituting greater uniformity across surgical practices and prioritizing the safety and outcomes of patients. The purpose of this study is to conduct a systematic review summarizing the major predictive models used to evaluate patients as candidates for spinal surgery. A search was conducted for articles related to predictive modeling in spinal surgeries using PubMed, MEDLINE, and Scopus databases. from Journal of the Neurological Sciences https://ift.tt/34KbbFz

The goal of Neurochecklists is to bring everything even remotely neurological under one roof. It set out to be a practical, comprehensive, easily searchable, on-the-go database. Sourcing information from reliable textbooks and journals, the database has slowly grown to peak today at >3,000 checklists spread across precisely 695 topics. These topics, in turn, are grouped […] What are the 695 topics that make up neurology? — Neurochecklists Blog from The Neurology Lounge https://ift.tt/3kWDJBi

Researchers discover how the brain adapts in a study of children born without a corpus callosum. from Neuroscience News https://ift.tt/3enTAXv

Haunted house experiment shows "just the right" amount of fear is key to maximizing enjoyment. from Neuroscience News https://ift.tt/3ebL51g

To investigate hypothesized sources of error when quantifying the effect of the sensory trick in cervical dystonia (CD) with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS-2), test strategies to mitigate them, and provide guidance for future research on the sensory trick. from Journal of the Neurological Sciences https://ift.tt/3ebgJfn

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Congratulations to Dr Michael Okun and his colleagues on their publication “ Patient-centred management of Parkinson’s disease – Authors’ reply ,” in the correspondence section of the November 1, 2020 issue of The Lancet Neurology.   from Department of Neurology » College of Medicine » University of Florida https://ift.tt/3jJxfVb

Mouse study links specific autism types to abnormal parvocellular oxytocin neurons in the hypothalamus. from Neuroscience News https://ift.tt/3jGadP0

Cocaine and sucrose neuron ensembles in the nucleus accumbens are mostly non-overlapping. from Neuroscience News https://ift.tt/3kHrW9Y

Study reveals how gene control mechanisms determine the identity of neurons in the embryonic brainstem. A failure in differentiation in developing brainstem neurons can lead to behavioral abnormalities, including ADHD. from Neuroscience News https://ift.tt/3mCEfVw

Skin safety is a hot-button issue for neurodiagnostic technologists, because EEG placement requires skin abrasion. Even this small amount of disruption to the skin’s protective barrier can increase infection risk. And November, which is American Diabetes Month , is a great time to learn the special measures you need to take to protect diabetic patients who are more prone to skin infection. Diabetes impairs blood flow and sensation in the skin, decreasing pain response. That means once a wound forms, it can remain open for long periods, increasing infection risk. Approximately 34 million people in the U.S. have diabetes and another 88 million adults have been diagnosed as prediabetic. The Standards and Practices Committee of ASET-The Neurodiagnostic Society recently created a Skin Safety Task Force  to address the increased infection risk for diabetics. Resources provided by the task force include: Position Paper on Skin Safety During EEG Procedures Skin Safety During EEG ...

Images create visual interest on your website and social media posts, and they can help you tell a great story. Images also are essential these days if you want your content to be noticed in an increasingly crowded web space. There are plenty of professional web designers and social media experts that will happily take your money and help you with this. But, if you run a small neurology practice and have more of a do-it-yourself budget, there’s a lot you can do to optimize your own images and get that professional look. With a little knowledge and some tricks of the trade you can deliver a high-quality and effective visual presence online . Know About Image Use Liability Running a medical practice comes with a lot of rules around liability and using images for marketing is no exception. Obviously, violating HIPAA laws using unauthorized pictures of patients will get you in trouble. What you may not know, though, is that violating copyright laws can also lead to huge fines – even ...

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Congratulations to Drs. Yoon Jin Choi, Stefan Delmas, Basma Yacoubi, David Vaillancourt, Michael Okun, and Evangelos Christou on the publication of “ Deep Brain Stimulation Reduces Midline Tremor During a Static Postural Balance Task in Essential Tremor Patients ,” in the November issue of Physical Medicine and Rehabilitation. Article information:  To determine the effect of deep brain stimulation (DBS) on midline tremor during a static balance in Essential Tremor patients. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/37Tf0KO

In this review, Luan et al. discuss the latest advances in engineering electrical neural interfaces that expand the spatiotemporal resolution and extent of mapping and manipulating brain circuits, covering implanted devices, integrated circuits, and signal transmission and processing. from journals https://ift.tt/3jzdVtx

Spastic paraplegia type 5 (SPG5/HSP-CYP7B1) is an autosomal recessive hereditary spastic paraplegia (HSP) caused by biallelic variants in the CYP7B1 gene, resulting in dysfunction of the enzyme oxysterol-7-α-hydroxylase. The consequent accumulation of hydroxycholesterols in plasma seems to be pathognomonic for SPG5, and represent a possible target for treatment. We aimed to characterize Norwegian patients with SPG5, including clinical examinations, genetic analyses, measurements of hydroxycholesterols, electrophysiological investigations and brain imaging. from Journal of the Neurological Sciences https://ift.tt/2HB5pxy

A new study reveals a correlation between multimedia multitasking, memory loss, and difficulties in maintaining attention. from Neuroscience News https://ift.tt/3mxnFXq

A tiny neural implant dubbed the Stentrode, allows people with upper limb paralysis to regain motor function. The device wirelessly restores the transmission of brain impulses. from Neuroscience News https://ift.tt/2G7Razj

Women aged 45 to 85 without partners and who didn't engage in frequent social activities had a higher rate of hypertension. Widowed women were most likely to exhibit symptoms of hypertension. from Neuroscience News https://ift.tt/2HIDBqE

Myeloid cells can suppress the immune response, allowing breast cancer cells to metastasize in the brain and form secondary tumor sites. from Neuroscience News https://ift.tt/2Twr7oq

The decline of striosomal activity in the brain may explain why people lose the motivation to learn as they age. from Neuroscience News https://ift.tt/3e5A8ON

This third and final special issue in our series on neurotechnology focuses on tools for modulating neural circuits. The first part of this series explored methods used to build and map networks, while the second part covered approaches to reading activity at different spatiotemporal scales. Here, in this final installment, we discuss large-scale electrode systems for recording, neural implants for manipulating central and peripheral signals, and considerations for translation of these technologies to the clinic. from journals https://ift.tt/2TB0vmc

Adult neurogenesis depends on the decision of neural stem cells to leave quiescence and become neurons. In this issue, Asrican et al. show that the neuropeptide cholecystokinin released by interneurons promotes the neuronal fate through astrocytic signaling. from journals https://ift.tt/2HL3Vk5

In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. from journals https://ift.tt/35EAqsl

In an interview with Neuron, Keith Kirkland, cofounder of a start-up building products that communicate information through touch, shares his path, passions, and life philosophy that brought him to launch a company. He also discusses the crucial need for representation in science and the value of self-empowered exploration and self-recovery from failure. from journals https://ift.tt/2HDjA4G

In an interview with Neuron, physicist and electrical engineer by training, Deblina Sarkar shares how her passion for the brain—“the ultimate example of a low-power computer”—inspires her research. She describes her work developing novel nanoelectronics devices and new biomolecular mapping methods to gain access to ultra-structures in the brain and discusses how she navigates across disciplines. from journals https://ift.tt/35I3GOF

Schiavone et al. describe the use of current characterization techniques to study electrode systems for neural stimulation, with focus on the specificities of soft technology. The authors provide guidelines to design complete in vivo characterization studies and interpret characterization data. from journals https://ift.tt/327o8rB

In this Perspective, Nurmikko provides an overview of the progress in cortical interfaces over the years. He considers the engineering challenges for chronic human use and discusses current strategies to scale electrical recording and stimulation up to thousands of neuronal targets at near-cellular-level resolution. from journals https://ift.tt/327o6jt

Shahriari, Rosenfeld, et al. discuss advances in technologies for recording and modulation of electrophysiological activity in the peripheral nervous system and organs. from journals https://ift.tt/2TwMExp

In their Perspective, Borton et al. describe the opportunities and challenges of scientific platforms to help catalyze translation of clinical neuroscience to therapeutic interventions. from journals https://ift.tt/35LfsI8

In this review, Luan et al. discuss the latest advances in engineering electrical neural interfaces that expand the spatiotemporal resolution and extent of mapping and manipulating brain circuits, covering implanted devices, integrated circuits, and signal transmission and processing. from journals https://ift.tt/3jzdVtx

Congratulations Drs. Shannon Y. Chiu , Wissam Deeb , Pamela Zeilman , Adolfo Ramirez-Zamora , Addie Patterson , Bhavana Patel , Kelly D. Foote , Michael S. Okun , and Leonardo Almeida on the publication of “ Brain Atrophy Following Deep Brain Stimulation: Management of a Moving Target ” in the October 21, 2020 issue of Tremor and Other Hyperkinetic Movements.   Abstract Clinical vignette:  A 51-year-old man with essential tremor (ET) had bilateral ventralis intermedius nucleus deep brain stimulation (VIM-DBS) placed to address refractory tremor. Despite well-placed DBS leads and adequate tremor response, he subsequently experienced worsening. Re-programming of the device and reconfirming the electrical thresholds for benefits and side effects were both performed. Six years following DBS implantation, repeat imaging revealed brain atrophy and a measured lead position change with a coincident change in clinical response. Clinical dilemma:  What do we know about brain at...

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This narrative review describes autologous hematopoietic stem cell transplant for multiple sclerosis, including recent developments, emerging guidelines for usage, and pending investigations. from journals https://ift.tt/3kBhEZ6

A mutation in a gene associated with circadian rhythm extends the clock period, causing people to stay up late at night and sleep late in the mornings. from Neuroscience News https://ift.tt/3jsLYnm

People don't tend to like those who show empathy to morally questionable individuals. from Neuroscience News https://ift.tt/324Yzr9

Study reveals one in four women experience symptoms of depression up to three years after giving birth. The risks are greater for women with a history of mood disorders and gestational diabetes. from Neuroscience News https://ift.tt/2Tu4v8d

Please join us for the  Movement Disorders and Neurorestoration Training Program 2020 Joint T32 & Movement Fellows Research Symposium Via Zoom Friday, October 30, 2020 9:00 am – 11:15 am   Zoom ID:  956 5339 9648 Passcode:  189370 See agenda here! from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2G4qPCn

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The brain processes motor commands, not just through fine muscle contractions, but also via higher-level motor areas that provide a blueprint for performing more complex motor functions, such as grasping, no matter if the toes or fingers are used. from Neuroscience News https://ift.tt/34wGa83

Mutations to the MARK4 gene causes the properties of tau to change, making them more likely to aggregate and become more insoluble. from Neuroscience News https://ift.tt/3otjcXm

Pigment-dispersing factor, a signalling protein that helps the brain keep track of time, also helps to regulate memory formation. from Neuroscience News https://ift.tt/35FXQ0r

Those who work in physically demanding jobs have a 55% higher risk of developing dementia than those who have more sedentary careers. from Neuroscience News https://ift.tt/37Iuzoi

Stroke, <a href="https://www.ahajournals.org/toc/str/51/11">Volume 51, Issue 11</a>, Page 3241-3249, November 1, 2020. Background and Purpose:More than half of patients with acute ischemic stroke have minor neurological deficits; however, the frequency and outcomes of reperfusion therapy in regular practice has not been well-delineated.Methods:Analysis of US National Inpatient Sample of hospitalizations with acute ischemic stroke and mild deficits (National Institutes of Health Stroke Scale [NIHSS] score 0–5) from October 1, 2016, to December 31, 2017. Patient- and hospital-level characteristics associated with use and outcome of reperfusion therapies were analyzed. Primary outcomes included excellent discharge disposition (discharge to home without assistance); poor discharge disposition (discharge to facility or death); in-hospital mortality; and radiological intracranial hemorrhage.Results:Among 179 710 acute ischemic stroke admissions with recorded NIHSS duri...

Stroke, <a href="https://www.ahajournals.org/toc/str/51/11">Volume 51, Issue 11</a>, Page e299-e300, November 1, 2020. from WoltersKluwer: Stroke: Table of Contents https://ift.tt/2HHqEgQ via IFTTT

Stroke, <a href="https://www.ahajournals.org/toc/str/51/11">Volume 51, Issue 11</a>, Page 3375-3381, November 1, 2020. There are substantial and longstanding inequities in stroke incidence, prevalence, care, and outcomes. The Health Equity and Actionable Disparities in Stroke: Understanding and Problem-Solving (HEADS-UP) symposium is an annual multidisciplinary scientific and educational forum targeting major inequities in cerebrovascular disease, with the ultimate objective of helping to bridge major inequities in stroke, and promptly translating scientific results into routine clinical practice, for the benefit of vulnerable and underserved populations. HEADS-UP is a collaborative undertaking by the National Institute of Neurological Disorders and Stroke and the American Stroke Association and is held the day before the annual International Stroke Conference. In 2020, the HEADS-UP focused on the topic of racial/ethnic disparities in stroke and comprised invited...

Stroke, <a href="https://www.ahajournals.org/toc/str/51/11">Volume 51, Issue 11</a>, Page 3382-3391, November 1, 2020. Race/ethnic minorities face significant inequities in stroke incidence, prevalence, care, and outcomes. The Health Equity and Actionable Disparities in Stroke: Understanding and Problem-solving symposium, a collaborative initiative of the American Heart Association and National Institute of Neurological Disorders and Stroke, was the first-ever annual multidisciplinary scientific forum focused on race/ethnic inequities in cerebrovascular disease, with the overarching goal of reducing inequities in stroke and accelerating the translation of research findings to improve outcomes for race/ethnic minorities. The symposium featured esteemed invited plenary speakers, lecturing on determinants of race/ethnic inequities in stroke and interventions aimed at redressing the inequities. The Edgar J. Kenton III Award recognized Ralph Sacco, MD, MS, for his lif...

Stroke, <a href="https://www.ahajournals.org/toc/str/51/11">Volume 51, Issue 11</a>, Page 3392-3405, November 1, 2020. Numerous epidemiological studies have demonstrated stroke disparities across race and ethnic groups. The goal of the NOMAS (Northern Manhattan Study) was to evaluate race and ethnic differences in stroke within a community with 3 different race-ethnic groups. Starting as a population-based incidence and case-control study, the study evolved into a cohort study. Results from NOMAS have demonstrated differences in stroke incidence, subtypes, risk factors, and outcomes. Disparities in ideal cardiovascular health can help explain many differences in stroke incidence and call for tailored risk factor modification through innovative portals to shift more diverse subjects to ideal cardiovascular health. The results of NOMAS and multiple other studies have provided foundational data to support interventions. Conceptual models to address health disparitie...

A 29-year-old G6P3023, left-handed woman presented with acute onset left-sided weakness and expressive aphasia. She was in her normal state of health while driving home from work when her mother noted symptom onset. She was taken immediately to the emergency department for further evaluation. On presentation, she was afebrile with blood pressure 136/99 mm Hg, regular heart and respiratory rates, and oxygen saturation 88% on room air. Neurologic examination was notable for left-sided hemiparesis and sensory disturbance. The aphasia had resolved. Emergent head CT did not demonstrate any abnormalities. from Neurology recent issues https://ift.tt/35yBGND

Overactivity in the subgenual anterior cingulate cortex underlies several key symptoms of depression, anxiety, and heart disease. from Neuroscience News https://ift.tt/35HIZmi

Testing multiple computational models of the nervous system, researchers discover that just because a model can make accurate predictions about data, this doesn't always translate into the underlying logic of the biological system it represents. from Neuroscience News https://ift.tt/3ouBTtW

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We evaluated cerebral gyri (CG) on phase difference enhanced imaging (PADRE) of corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Parkinson's disease (PD) patients to determine whether it is possible to discriminate among them on an individual basis. Two radiologists reviewed appearance of the normal CG and that of CBS patients on PADRE, and deviations from the appearance of the normal CG were recorded. Next, based on the CG abnormalities, two other reviewers reviewed PADRE images from 12 CBS, 14 PSP, and 30 PD patients. from Journal of the Neurological Sciences https://ift.tt/3oqTnHC

Male and female rodents exhibit distinct symptoms and brain features of both PTSD and alcohol use disorder. Following trauma, males show increased GABA receptor function, while females showed increased GABA release. from Neuroscience News https://ift.tt/31EANBI

Contrast-induced neurotoxicity (CIN) is a rare complication of neurointerventional procedures and its understanding remains limited. We evaluated the association of CIN with systemic hemodynamics in patients undergoing neuroendovascular interventions. from Journal of the Neurological Sciences https://ift.tt/3e1l6d6

Exploring Neurochecklists is a revealing experience… It always highlights the expansive range of neurological disorders. To illustrate this extensive breadth and scope of neurology… Here are 83 striking numbers..all linked to their checklists. 83. Numbers in a city: New Haven, CT. See Ming-Lee on Flickr https://www.flickr.com/photos/seeminglee/142117353 11 neurological complications of aortic dissection 11 causes of […] The remarkable scope of neurology…in 83 revealing numbers — Neurochecklists Blog from The Neurology Lounge https://ift.tt/34r0K9G

Dysfunction in brain cells caused by low oxygen is caused by the same responder system that is intended to be protective. from Neuroscience News https://ift.tt/3mby8aC

Study reveals the body produces more cortisol when people are interrupted during work. from Neuroscience News https://ift.tt/3oj65rH

Increasing time spent sleeping immediately following a traumatic event can help to significantly reduce the effects of trauma. from Neuroscience News https://ift.tt/3jrycBn

Study reveals a new role for serotonin in the development of the human neocortex. Serotonin acts cell-extrinsically as a growth factor for basal progenitors in the developing neocortex. Researchers report placenta-driven serotonin likely contributed to the evolutionary expansion of the neocortex in humans. from Neuroscience News https://ift.tt/2Hwoctz

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Certain parts of the brain are considered prime real estate. This is how neurologist Dr. Jeffrey Gertsch describes the eloquent cortex, the part of the brain where vital functions like language and motor function originate. Surgeons working in these areas need to carefully map the brain in real time, and neurodiagnostic technologists play an important role. This was the message of Dr. Gertsch’s talk at the recent annual meeting held by ASET-The Neurodiagnostic Society. Intraoperative brain mapping “is manpower- and equipment-intensive,” he said. Many subspecialties need to be coordinated and that includes the technologist. Brain mapping is typically used during epilepsy and tumor removal surgeries in the eloquent cortex. This includes areas near the temporal and frontal lobes where critical functions like speech, movement, hearing, vision, memory, and touch are centered. Most people generally share these locations in common, but there is slight variation from person to person and...

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Incidental imaging findings are abnormalities of potential clinical significance discovered unintentionally that are not related to the symptoms that prompted the test [1]. Their identification frequently leads to adverse psychological and social consequences [2,3]. Knowledge of the concept of incidental findings prior to imaging may enhance patient autonomy and reduce anxiety in the event that an incidental finding is subsequently identified [4]. However, the risk of incidental findings is frequently not discussed in clinical practice. from Journal of the Neurological Sciences https://ift.tt/2HhHjYw

Researchers report spirituality may be a component of wisdom, but pro-social behaviors such as empathy and compassion are more critical elements. from Neuroscience News https://ift.tt/37uBwcE

Study reports a metabolite produced following the consumption of dietary soy may lower risk factors for dementia. from Neuroscience News https://ift.tt/2Ht1CC2

Neuroimaging newborns reveals the human brain is born "prewired" to be receptive to words and language. from Neuroscience News https://ift.tt/3kqcnDx

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A new drug combination tested in a multisite human clinical trial shows promise for slowing the progression of ALS, often called Lou Gehrig’s disease, researchers at the University of Florida and partner institutions reported in The New England Journal of Medicine. The oral drug, a combination of sodium phenylbutyrate and taurursodiol, was tested in the Phase 2 CENTAUR trial, a placebo-controlled, randomized, double-blind trial of 137 ALS patients within 18 months of onset of symptoms. The compounds, which previously were found to reduce neuronal death in preclinical models, resulted in statistically significant slowing of disease progression in the human trial, according to the study. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2Tjr3Zm

Todd Barnes knows the business of neurology. With an MBA and more than 20 years of experience he has become an expert in navigating the financial travails increasingly faced by this group of physicians. He knows that sometimes neurologists want to supplement their income, and he knows what opportunities are available. He gave a talk on this subject at the last meeting of the American Academy of Neurology. We were fortunate enough to meet him then and more recently ask him more about this issue. The result was a series of articles we published on medical legal work, consulting for insurance companies , and doing intermittent locum tenens . This post is the last of that series and it focuses on doing side work for the U.S. Department of Veterans Affairs. Todd Barnes The VA has hospitals and medical centers across the country and “the money can be good, especially for the amount of work you are asked to do,” says Barnes. The VA uses a system of “eighths” to determine the amount ...

A new drug combination tested in a multisite human clinical trial shows promise for slowing the progression of ALS, often called Lou Gehrig’s disease, researchers at the University of Florida and partner institutions reported in The New England Journal of Medicine. The oral drug, a combination of sodium phenylbutyrate and taurursodiol, was tested in the Phase 2 CENTAUR trial, a placebo-controlled, randomized, double-blind trial of 137 ALS patients within 18 months of onset of symptoms. The compounds, which previously were found to reduce neuronal death in preclinical models, resulted in statistically significant slowing of disease progression in the human trial, according to the study. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2Tjr3Zm

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Cannabis use is on the rise both as medical treatment and recreational use. There is evidence that cannabis can cause hallucinations and psychosis especially with heavy and prolonged use. Parkinson's disease (PD) carries an increased risk for development of hallucinations and psychosis. It is possible that cannabis may exacerbate this risk and result in earlier and greater amounts of hallucinations and psychosis in this vulnerable population. A literature review was performed to determine the answer to that question. from Journal of the Neurological Sciences https://ift.tt/2IVfDJk

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Herpes simplex viruses (HSV) are neurotropic and known to cause central nervous system (CNS) infections. We aimed to describe the clinical and imaging features of cerebrovascular complications in patients with HSV CNS infections. from Journal of the Neurological Sciences https://ift.tt/34ktH7x

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Research productivity is a key criterion for applicant selection reported by residency program directors. Research volume reported on neurosurgery residency applications has risen steadily over the past decade. from Journal of the Neurological Sciences https://ift.tt/3kpE8Mw

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Researchers have identified a brain pathway between the ventrolateral prefrontal cortex and the inferior temporal cortex which enables primates to effortlessly identify objects in their field of vision. from Neuroscience News https://ift.tt/2HneBoz