NEURO

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Author: Michel Ferrari, Andrew Charles, David Dodick, Fumihiko Sakai, and Joost Haan ISBN: 9780198724322 Binding: Hardcover Publication Date: 01 June 2020 Price: $185.00 from journals https://ift.tt/3dnJww5

Abnormal sensory processing associated with ASD has been linked to weaker neural suppression in the visual cortex. from Neuroscience News https://ift.tt/2TYolsZ

Fellows’ Journal Club The authors evaluated a total of 426 unruptured aneurysms and 169 ruptured aneurysms that underwent coil embolization in their institution between January 2009 and December 2017. Recanalization occurred in 38 (8.9%) of 426 unruptured aneurysms and 37 (21.9%) of 169 ruptured aneurysms. The Modified Raymond-Roy Classification on DSA was used to categorize the recanalization type. In untreated recanalized aneurysms, class IIIb aneurysms ruptured significantly more frequently than class II and IIIa. In the ruptured group, the median follow-up term was 28.0 months. Retreatment for recanalization was performed in 16 aneurysms. Four of 21 untreated recanalized aneurysms (2.37% of total coiled aneurysms) ruptured. Class IIIb aneurysms ruptured significantly more frequently than class II and IIIa. Coiled aneurysms with class IIIb recanalization should undergo early retreatment because of an increased rupture risk. Abstract DSA findings for ruptured recanalized ane...

Distal myopathies encompass a group of hereditary or less commonly acquired disorders of skeletal muscles with predominant or selective weakness and wasting of the distal muscles. Although their clinical and histopathological heterogeneity often poses a diagnostic challenge, the detailed pattern of distal weakness, certain specific histopathological findings and associated clinical features can help guide the genetic test and eventually achieve the correct diagnosis [1]. We describe a case of childhood-onset refractory thrombocytopenia and early adult-onset distal weakness due to compound known and novel heterozygous mutations in GNE gene that encodes bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. from Journal of the Neurological Sciences https://ift.tt/304iqqf

Non-substance addictive behaviors may involve repetitive rewarding behaviors including gambling, gaming, sexual activities, internet-use, and buying-shopping. In addictions, there exists diminished control over participation in the behaviors and continuation of the behaviors despite experiencing negative consequences. Addictive participation in behaviors typically results in distress and functional impairment in personal, relational, occupational, educational or other life domains. Increases in cue-reactivity and craving and decreases in inhibitory control may represent pivotal mechanisms in addictions, especially when behavior-specific cues are present. from Journal of the Neurological Sciences https://ift.tt/2MfjHlX

Study reports SARS-CoV-2, the virus that causes COVID-19, was well suited to making the jump from animals to humans by shapeshifting as it gained the ability to infect human cells. The virus's ability to infect humans occurred via exchanging gene fragments from a coronavirus that infected pangolins. The species-to-species transmission was a result of the ability of SARS-CoV-2 to bind to host cells through alterations to its genetic material. from Neuroscience News https://ift.tt/2XMsGjU

Changes in gut mucus may contribute to Alzheimer's, Parkinson's, and other neurological disorders. Researchers noted changes in types of gut mucus bacteria in those with a range of neurological disorders compared to their healthy peers. Findings suggest those with reduced gut mucus protection may be more susceptible to gastrointestinal problems. from Neuroscience News https://ift.tt/2ZUjUmC

Editor’s Choice In this review, the authors provide an appraisal of the current literature on the physics principles, histopathologic validation, and clinical applications of advanced diffusion techniques in both brains and spinal cords of patients with MS (neurite orientation dispersion and density imaging, diffusion basis spectrum imaging, multicompartment microscopic diffusion MR imaging with the spherical mean technique, and models enabled through high-gradient diffusion MR imaging). They discuss limitations of each of the methods and directions that future research could take to provide additional validation of their roles as biomarkers of axonal and myelin injury in MS. Abstract Conventional MR imaging techniques are sensitive to pathologic changes of the brain and spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity. By isolating the signal contribution from different tissue compartments, newly developed advanced multicompartment d...

Delirium frequently complicates acute stroke and worsens outcomes. Because delirium is potentially preventable, predicting its occurrence is essential. Although several prediction scores have been proposed, nurses need to quickly predict delirium in stroke care units (SCUs). We aimed to develop a simple tool for this purpose by examining a comprehensive set of potential predictors. from Journal of the Neurological Sciences https://ift.tt/3ccpiUB

The role of metabolically unhealthy (MU) overweight in influencing stroke prognosis has not been fully assessed and conclusive data about the impact of sex are lacking. Aim of this study was to evaluate the possible correlations among MU overweight, sex and ischemic stroke severity and outcome. from Journal of the Neurological Sciences https://ift.tt/2XH1jb7

Tests of rapid automatized naming (RAN) have been used for decades to evaluate neurological conditions. RAN tests require extensive brain pathways involving visual perception, memory, eye movements and language. To the extent that different naming tasks capture varied visual pathways and related networks, we developed the Staggered Uneven Number (SUN) test of rapid number naming to complement existing RAN tests, such as the Mobile Universal Lexicon Evaluation System (MULES). The purpose of this investigation was to determine values for time scores for SUN, and to compare test characteristics between SUN and MULES. from Journal of the Neurological Sciences https://ift.tt/2AqE0KM

This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complications of coronavirus disease 2019. from journals https://ift.tt/3gAs6hV

This case report describes a 25-year-old female radiographer with no significant medical history who had been working in a coronavirus disease 2019 (COVID-19) ward who presented with a mild dry cough that lasted for 1 day, followed by persistent severe anosmia and dysgeusia. from journals https://ift.tt/3gtheSO

Dopamine neurons in the substantia nigra pars compacta (SNpc) are highly energy demanding and vulnerable to stressful condition [1]. Selective vulnerability of DNs was underscored in Parkinson's disease (PD), but is being challenged by current concept of spreading pathologies. Thus, non-degenerative conditions will be more advantageous than degenerative ones to investigate SVDN. Herein we report the development of hemiparkinsonism in a young female after contralateral midbrain compression (Kernohan notch, KN) secondary to intracerebral hemorrhage (ICH), demonstrating vulnerability of dopamine neurons. from Journal of the Neurological Sciences https://ift.tt/2BhcQGz

Idiopathic Generalized Epilepsy (IGE) management has become increasingly challenging due to the restricted use of Valproate (VPA) in females. The aim of the study was to assess possible differences in terms of seizure outcome between men and women suffering from IGE. from Journal of the Neurological Sciences https://ift.tt/2M8zWBg

Researchers used data of active COVID-19 case rates from China to set the parameters for the model. Applying the formula to other counties, including the UK, France, and Brazil, they found a match in the evolution of active cases and fatality rates over time. from Neuroscience News https://ift.tt/3ds18qV

Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta. from Neuroscience News https://ift.tt/2M8NJaT

Age, sex, and gender influence the organization of the brain's opioid system. Findings shed light on why there are significant differences between the opioid system on an individual level, and why some are more prone to developing opioid-linked pathologies than others. from Neuroscience News https://ift.tt/2Bi8aAl

Exposure to anesthesia causes lipid clusters to move from an ordered state to a disordered one, then back again. These changes lead to subsequent effects that cause changes in consciousness. from Neuroscience News https://ift.tt/3dhieY7

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Intracranial artery stenosis (ICAS) is a leading cause of stroke worldwide. It is estimated to account for 10% of ischemic strokes in the US and perhaps up to 50% of strokes in Asia. Despite its frequency and role in stroke-related morbidity and mortality, ICAS has received less attention compared with extracranial atherosclerotic disease. In the past 15 years, clinical trials have refined the treatment approach for patients with recent stroke or transient ischemic attack (TIA) and ICAS. However, less information is available pertaining to asymptomatic ICAS. from journals https://ift.tt/36vQ4pW

Clinical and optic disc characteristics of patients showing visual recovery in Leber hereditary optic neuropathy. Moon Y, Kim US, Han J, Ahn H, Lim HT. J Neuroophthalmol 2020; 40:15-21. Abstract BACKGROUND: The visual prognosis in Leber hereditary optic neuropathy (LHON) is generally poor. However, some individuals can have spontaneous visual recovery (VR) in one or […] via What are the predictive factors of visual recovery in Leber hereditary optic neuropathy? — Neurochecklists Blog from The Neurology Lounge https://ift.tt/3gzclYx

A new study reveals up to 30% of children diagnosed with autism had less severe symptoms at age six than they did at age three. In some cases, children lost their autism diagnoses entirely. Girls are more likely to show a greater reduction in autism symptoms and less of a rise in the severity of symptoms than boys on the autism spectrum. from Neuroscience News https://ift.tt/3gtymYG

Despite pneumonia being an emerging burden on Parkinson's disease patients, there is essentially nothing known on whether they are at an increased risk of pneumonia occurrence and their associated factors. from Journal of the Neurological Sciences https://ift.tt/2yM6LkA

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Neuroimaging study sheds new light on how we perceive colors. Activity in higher visual cortex areas matched the colors test subjects saw. from Neuroscience News https://ift.tt/3gxJVy4

We read with interest the article by Ghosh and colleagues describing an adolescent male who presented with primary hypoparathyroidism and extensive neurological involvement [2]; the authors conclude that the mitochondrial DNA (mtDNA; NC_012920.1) variant, m.15043G>A within MT-CYB is pathogenic and responsible for the patient's neurological presentation. from Journal of the Neurological Sciences https://ift.tt/2M90dzi

We appreciate the criticism raised by Dr. Alston and colleagues questioning the pathogenicity of the m.15043G > A variant [1]. Irrespective of the question if the variant was responsible for the phenotype or not, there was clinical evidence that the described patient had indeed a mitochondrial disorder. The patient presented with a multisystem phenotype, including focal/generalized seizures, moderate cognitive decline, choreo-ballism, sensori-neural hearing loss (SNHL), primary hypoparathyroidism, myopathy (ptosis), neuropathy, and elevated serum / cerebrospinal fluid (CSF) lactate and pyruvate. from Journal of the Neurological Sciences https://ift.tt/2ZKCUUH

Artificial intelligence reveals how the brain programs procedural knowledge. from Neuroscience News https://ift.tt/2yGAJ9z

People fail to process information that contradicts their convictions. A new study explains the neural processes that contribute to confirmation bias. from Neuroscience News https://ift.tt/3gsGRDv

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This phase 2 randomized clinical trial evaluates the safety, tolerability, and efficacy of viltolarsen in boys with Duchenne muscular dystrophy amenable to exon 53 skipping from journals https://ift.tt/3gqTDlW

This cohort study examines the age-specific prevalence and prognosis of asymptomatic intracranial stenosis in British patients with transient ischemic attack and minor stroke. from journals https://ift.tt/3gxvaLR

This randomized clinical trial compares 3 treatment strategies among patients with medication overuse headache in Denmark. from journals https://ift.tt/3emPT2L

Parkinson's disease (PD) patients develop levodopa induced dyskinesia with disease progression from sensitization of central pathways. Pain pathways are also impacted with suggestions dyskinetic patients may process pain differently. from Journal of the Neurological Sciences https://ift.tt/2AhdCCI

Altered mental state and strokes are the most common neurological symptoms associated with coronavirus infection. from Neuroscience News https://ift.tt/3d9Dnng

Researchers have identified a hippocampal neural network that activates during stress. Activity in a hippocampal-hypothalamus network predicts greater feelings of stress, while connectivity between the hippocampus and dorsolateral prefrontal cortex predicts less stress. from Neuroscience News https://ift.tt/2ZGH6of

Congratulations Drs. Hess, Foote, Okun, Shukla, and Vaillancourt on the publication of “Quantitative Separation of Tremor and Ataxia in Essential Tremor.”  This article was published in the May 17th edition of Annuals of Neurology.   Abstract Objective This study addresses a very important problem in Neurology, distinguishing tremor and ataxia using quantitative methods. Specifically, we aimed to quantitatively separate dysmetria, a cardinal sign of ataxia, from tremor in Essential Tremor (ET). Methods In experiment 1, we compared nineteen participants diagnosed with ET undergoing thalamic deep brain stimulation (DBS; ET DBS ) to 19 healthy controls (HC). We quantified tremor during postural tasks using accelerometry and dysmetria with fast, reverse‐at‐target goal‐directed movements. To ensure that endpoint accuracy was unaffected by tremor, we quantified dysmetria in selected trials manifesting a smooth trajectory to the endpoint. Finally, we manipulated tremor ampl...

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Maintaining deep brain stimulation, or DBS, devices has become more challenging during the COVID-19 crisis. In a new Neurology Today article, Dr. Michael S. Okun, chair of  University of Florida  neurology and executive director of the  Norman Fixel Institute for Neurological Diseases at UF Health , discusses these challenges and the recommendations he co-authored the Journal of Parkinson’s Disease to help guide the field forward. “We wanted to get information out not only to neurologists and neurosurgeons, but to general practitioners and to patients who need to understand what can and can’t be done, and what can be performed through telemedicine,” Okun said. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2X6hvmV

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Serotonin syndrome (SS) is a potentially life-threatening drug-induced disorder mediated by serotoninergic over-activity at synapses of the central and peripheral nervous system [1]. The fixed combination of lopinavir/ritonavir (LPV/r) has been widely used during the present Coronavirus Disease 2019 (COVID-19) pandemic [2]. Ritonavir has, however, been shown to trigger SS in HIV-infected individuals [3]. We here provide the first report of two COVID-19 patients who developed SS. from Journal of the Neurological Sciences https://ift.tt/3d78CPP

It is critical that Randomized Controlled Trials(RCTs) present complete and transparent reporting. The present study aims to determine the reporting quality of double-blind RCTs for medicinal interventions in patients with ischemic stroke, based on the 2010 CONSORT-statement. from Journal of the Neurological Sciences https://ift.tt/2X7pwYZ

A 50 year-old man with controlled hypertension and type II diabetes presented after one week of dyspnea and cough with a blood O2 saturation of 90%. A Reverse Transcriptase-Polymerase Chain Reaction assay on a nasopharyngeal swab specimen confirmed severe acute respiratory syndrome coronavirus 2, and a diagnosis of coronavirus disease 2019 (COVID-19) pneumonia. On initial neurologic examination, the patient was alert and fully oriented with fluent speech and no focal deficits. On the second hospital day and while on 2L of supplemental O2 through nasal cannula, blood O2 saturation dropped to 70% and he was intubated. from Journal of the Neurological Sciences https://ift.tt/2LZSCmy

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is an infection-associated encephalitis/encephalopathy syndrome that is predominately caused by a viral infection [1]. Herein, we describe the first presumed case of coronavirus disease 2019 (COVID-19)-associated MERS. from Journal of the Neurological Sciences https://ift.tt/3c68oar

Helius’s short-term treatment PoNS device has been approved for use in Canada, and is intended to be used alongside physical therapy for gait deficit due to mild and moderate symptoms of MS. from Front page feed https://ift.tt/2M3j9zr

Avadel seeks to have its sodium oxybate agent be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy. from Front page feed https://ift.tt/3di8opf

Amid swirling reports of associations between stroke and the novel coronavirus, as well as the impact the pandemic has had on stroke care, new recommendations to maintain care expectations have been suggested by a diverse group of stroke experts. from Front page feed https://ift.tt/2ZJi6gb

Educational sessions led by experts in multiple sclerosis will be held May 26-29, 2020. from Front page feed https://ift.tt/2TEC3RG

The new data further cemented the therapy’s consistent safety profile from previous studies as well as demonstrated a newfound durability in patients with later-onset spinal muscular atrophy.  from Front page feed https://ift.tt/3dhFyoA

During the COVID-19 pandemic, it is more important than ever to ensure that a patient with stroke is transferred to the right hospital the first time around. from Front page feed https://ift.tt/2X4X2iw

While the amount of antibodies generated varies widely in patients who have recovered from coronavirus, most people generate at least some antibodies which are intrinsically capable of neutralizing the SARS-CoV-2 virus. from Neuroscience News https://ift.tt/3d6u4o2

Rat study suggests prenatal microbial exposure influences neurodevelopmental outcomes. from Neuroscience News https://ift.tt/2M2Ba0Y

BIOS health is partnering with Canadian universities to develop an artificial intelligence closed-loop neuromodulation system for chronic cardiac conditions. from Neuroscience News https://ift.tt/3cbVzvj

After natural killer immune cells kill virus-infected cells, T and B immune cells produce cytokines. This makes the immune reaction stronger and results in the cytokine storm associated with severe COVID-19 infection. from Neuroscience News https://ift.tt/2M30eVI

Researchers have developed a new, sophisticated device that delivers vagus nerve stimulation to help treat chronic pain. from Neuroscience News https://ift.tt/2M2UqeC

A new study reports hyper-connectivity between substructures of the thalamus, and the cerebral cortex may be responsible for auditory hallucinations associated with schizophrenia. from Neuroscience News https://ift.tt/2X4Awq8

Researchers have developed a new model of early embryonic brain development. The model, called MiSTR, allows researchers to create tissue that contains different brain regions and place them next to each other. The model produces results similar to embryonic brain development at five weeks post-fertilization. from Neuroscience News https://ift.tt/2X4XBck

Use this link to download a copy of NF Hero Comics – Understanding NF2.  This is a resource from the Children’s Tumor Foundation – Ending NF through Research.   from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2ZImzQf

Ending Parkinson’s Disease:  Live is a series of free webcasts highlighting key aspects of our fight against this disease: prevention, advocacy, care and treatement.   A conversation with Lonnie Ali   May 27, 2020 1:00pm Register here! from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2X86m5r

Congratulations Dr. Janis Daly on the publication of “ Development of a Combined, Sequential Real-Time fMRI and fNIRS Neurofeedback System Enhance Motor Learning After Stroke,” which appeared in the May 18th online edition of Journal of Neuroscience Methods. Abstract Background. After stroke, wrist extension dyscoordination precludes functional arm/hand. We developed a more spatially precise brain signal for use in brain computer interface (BCI’s) for stroke survivors. New Method Combination BCI protocol of real-time functional magnetic resonance imaging (rt-fMRI) sequentially followed by functional near infrared spectroscopy (rt-fNIRS) neurofeedback, interleaved with motor learning sessions without neural feedback. Custom Matlab and Python code was developed to provide rt-fNIRS-based feedback to the chronic stroke survivor, system tester. Results The user achieved a maximum of 71% brain signal accuracy during rt-fNIRS neural training; progressive focus of brain activation a...

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A new smart device can measure electrical signals from your skin, providing the potential to track your emotions and stress level. from Neuroscience News https://ift.tt/36wMtYv

People with the Alzheimer's associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developing severe coronavirus symptoms compared to those who those with the common e3e3 form of the APOE gene. from Neuroscience News https://ift.tt/2M2ukZs

Stroke, <a href="https://www.ahajournals.org/toc/str/51/6">Volume 51, Issue 6</a>, Page 1639-1639, June 1, 2020. from WoltersKluwer: Stroke: Table of Contents https://ift.tt/2X3Tygn via IFTTT

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A 17-year-old African Brazilian woman presented with a 1-year history of progressive ataxia, dysarthria, and decreased visual acuity. Family history was remarkable for multiple relatives with similar motor symptoms but no visual complaints. Examination showed upward gaze palsy, dysarthria, ataxia, and increased tone and reflexes. Fundoscopic examination and subsequent optical coherence tomography revealed bilateral atrophic maculopathy (figures 1 and 2). Genetic testing confirmed the diagnosis of spinocerebellar ataxia type 3 (SCA3) by revealing abnormal CAG repeats in the ATXN3 gene—the pathologic allele had 68 repeats and the normal allele 14 repeats. from Neurology recent issues https://ift.tt/2TCOGMY

A 28-year-old man had experienced binocular diplopia for the last 2 months. Around the same time, he noticed mostly nocturnal polyuria and polydipsia and eventually was diagnosed with diabetes insipidus. Extraocular motility testing demonstrated jerky convergence movements on an attempted upgaze and mild lid retraction (video 1). Urgent MRI of the brain revealed a large mass in the dorsal midbrain region, which was also compressing the hypothalamus (figure). The lesion was biopsied and a diagnosis of primary intracranial germinoma arising from pineal tissue was made. Treatment with low-dose radiotherapy commenced. Characteristic clinical features of convergence retraction nystagmus in this case allowed rapid localization of the lesion, its diagnosis, and eventually treatment. 1 from Neurology recent issues https://ift.tt/2Xw4bHs

In this issue of Neurology ®, the authors of this study determined whether daridorexant, a new sleep medication, was safe and effective in treating insomnia for adults >65 years of age. 1 Insomnia is difficulty falling asleep or staying asleep that may interfere with daytime functioning, including an increased risk for falls, mood disorders such as depression, and decreased quality of life. 2,3 It can be seen in about half of older adults. There are treatments, but commonly used medications for insomnia in older adults can increase the risk of thinking problems and falls. 2,3 from Neurology recent issues https://ift.tt/2TEBiYF

Researchers have identified 6,822 mutations of SARS-CoV-2 across a global dataset. 273 mutations have occurred repeatedly and independently. Of those, researchers investigated 31 mutations that have occurred at least ten times during the current pandemic. They found no evidence that any of the common mutations are increasing the ability of the virus to be transmitted. Some common mutations are neutral, but most are mildly detrimental to the virus. New evidence also suggests the viral spike protein, D614G, is not associated with increased viral transmission. from Neuroscience News https://ift.tt/2zlpWSF

By the age of six months, infants can recognize when an adult imitates them and perceive the imitator as more friendly. from Neuroscience News https://ift.tt/3gluY28

Researchers isolated live SARS-CoV-2, the virus responsible for COVID-19, from the feces of patients who died as a result of coronavirus infection. Antigens to the virus were also found in post-mortem gastrointestinal surface cells. Isolating the live virus from fecal matter indicates evidence of the infectious virus in feces is a common manifestation of COVID-19. Researchers also found SARS-CoV-2 RNA on surfaces and bedding samples in hotel rooms used by two presymptomatic people who were later diagnosed with COVID-19. from Neuroscience News https://ift.tt/3gk58eI

Activity in the frontoparietal network during memory tasks reflected the individual working memory capabilities of children, with an activity pattern unique to working memory. from Neuroscience News https://ift.tt/36AdY3x

Researchers have identified 29 genetic variants linked to problematic alcohol use. Nineteen of the genes were previously unknown independent risk factors for alcohol use disorder. from Neuroscience News https://ift.tt/3bYRtWX

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It is becoming apparent that patients with COVID-19 are developing a wide variety of autoimmune syndromes many of which involve the nervous system (Table 1). These syndromes most often occur when patients are recovering from the acute viral symptoms. Even in patients with active infection in the lungs, the inflammatory response to the viral infection can be overwhelming in some which is thought to be the major cause of acute respiratory distress syndrome or the viral pneumonia [1,2]. The inflammation is also thought to mediate a hypercoagulable state leading to thromboses in multiple blood vessels and organ systems including the brain [3,4]. from Journal of the Neurological Sciences https://ift.tt/3gh37Qu

As we have seen, the coronavirus pandemic has substantially cut the demand for EEG testing and even resulted in loss of work for some technologists. Now, with growing evidence that the virus can cause neurological complications, the use of EEG testing will likely increase. So say the authors of a new paper offering an enhanced safety protocol for performing EEGs on patients with COVID-19. Due to the many unknowns and highly contagious nature of this virus, researchers in the Neurodiagnostic Department at Medical City Dallas Hospital felt they needed to go beyond standard infection control measures. They applied a new EEG workflow in a case study published in Neurodiagnostic Journal this April. Their patient (a 73-year-old male) was in acute respiratory failure, requiring intubation in the hospital’s COVID-19 ICU unit. The patient experienced a convulsion-like episode with transient left-sided facial droop while being weaned from sedation. The patient was too unstable to undergo...

Dr. Tait Shanafelt’s name comes up often when talking about physician burnout. For nearly two decades he has been studying its impact on the healthcare workforce and the ways people and institutions successfully mitigate the problem. Now he has some insight for leadership during the COVID-19 pandemic, a time of unprecedented anxiety among healthcare professionals. “At the same time they cope with the societal shifts and emotional stressors faced by all people, health care professionals face greater risk of exposure, extreme workloads, moral dilemmas, and a rapidly evolving practice environment,” Shanafelt and his co-authors wrote in this Viewpoint , published last month in JAMA. Given the likely duration of this pandemic, these issues need sustainable solutions and they need to come from leadership — people like hospital executives, nursing heads, department chairs, and division chiefs. It is not enough for leaders to offer “generic approaches to stress reduction or resilience,” ...

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Treating coronavirus patients with alpha-blockers may help prevent the cytokine storm associated with severe COVID-19 infection. Alpha-blockers interfere with the cell signaling that triggers cytokine storms. Mice with bacterial infections that were treated with alpha-blockers experienced reduced cytokine storms and decreased death rates. from Neuroscience News https://ift.tt/2TAw0gI

Children exposed to maternal antenatal corticosteroids had higher rates of emotional, behavioral, and psychological developmental disorders than their peers whose mothers did not take the drug. from Neuroscience News https://ift.tt/2TC2gQy

Recovered stroke patients who suffer from sleep-wake disruptions are more likely to experience another stroke, researchers report. from Neuroscience News https://ift.tt/3d0uxIf

Coronavirus patients treated with chloroquine or hydroxychloroquine are significantly more likely to experience ventricular arrhythmias than those who were treated with other medications. The study also revealed that out of 100,000 COVID-19 patients who were hospitalized, the 15,000 who received hydroxychloroquine were more likely to have worse health outcomes than those treated with other drugs. from Neuroscience News https://ift.tt/2zqGYP5

Study reveals when empathetic accuracy is beneficial, and also harmful, to relationships. from Neuroscience News https://ift.tt/3gaoq6a

Higher levels of air pollution associated with urban living could put people at a 29% increased risk of multiple sclerosis. from Neuroscience News https://ift.tt/36njq9Z

Safety and efficacy of dual antiplatelet pretreatment in patients with ischemic stroke treated with IV thrombolysis: a systematic review and meta-analysis. Malhotra K, Katsanos AH, Goyal N, et al. Neurology 2020; 94:e657-e666. Abstract OBJECTIVE: Conflicting data exist on the safety and efficacy of IV thrombolysis (IVT) in patients with acute ischemic stroke (AIS) receiving dual […] via Is the bleeding risk of thrombolysis increased in those on dual antiplatelets? — Neurochecklists Blog from The Neurology Lounge https://ift.tt/3ggNFUx

This case-control study examines the use of fluorine 18–labeled fluorodeoxyglucose positron emission tomographic imaging to detect glucose metabolic changes in individuals who are presymptomatic carriers of a mutation in the C9orf72 gene that leads to amyotrophic lateral sclerosis and frontotemporal dementia. from journals https://ift.tt/2ZrWB3c

We present a case series of posterior reversible encephalopathy syndrome (PRES) in two patients hospitalized with acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-19), possibly a manifestation of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). from Journal of the Neurological Sciences https://ift.tt/3bVzj8H

Study reveals how sensory neurons regulate sleep-wake cycles. from Neuroscience News https://ift.tt/3cWIdnB

Researchers have developed a sniff test that can detect which patients in a vegetative state following a TBI will regain consciousness. from Neuroscience News https://ift.tt/3gc4kZf

Severe adversity experienced in childhood increases the risk of being diagnosed with ADHD later in life. from Neuroscience News https://ift.tt/2WUNuqg