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Serotonin syndrome in two COVID-19 patients treated with lopinavir/ritonavir

Serotonin syndrome (SS) is a potentially life-threatening drug-induced disorder mediated by serotoninergic over-activity at synapses of the central and peripheral nervous system [1]. The fixed combination of lopinavir/ritonavir (LPV/r) has been widely used during the present Coronavirus Disease 2019 (COVID-19) pandemic [2]. Ritonavir has, however, been shown to trigger SS in HIV-infected individuals [3]. We here provide the first report of two COVID-19 patients who developed SS.

from Journal of the Neurological Sciences https://ift.tt/3d78CPP
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