In vivo demonstration of selective vulnerability of dopamine neurons

Dopamine neurons in the substantia nigra pars compacta (SNpc) are highly energy demanding and vulnerable to stressful condition [1]. Selective vulnerability of DNs was underscored in Parkinson's disease (PD), but is being challenged by current concept of spreading pathologies. Thus, non-degenerative conditions will be more advantageous than degenerative ones to investigate SVDN. Herein we report the development of hemiparkinsonism in a young female after contralateral midbrain compression (Kernohan notch, KN) secondary to intracerebral hemorrhage (ICH), demonstrating vulnerability of dopamine neurons.

from Journal of the Neurological Sciences https://ift.tt/2BhcQGz