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Showing posts from July, 2020

A Centerpiece of Ebrains’ Human Brain Atlas

A new human brain atlas features 250 structurally distinct areas, each based on the analysis of ten brains. Over 2400 brain sections were digitalized and assembled in 3D to create the new map. from Neuroscience News https://ift.tt/3ghwJNp
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Multiple sclerosis in Pakistan: Current status and future perspective

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) which commonly leads to disability. We reviewed articles on MS from Pakistan using PubMed, Google Scholar and Pak Medinet to present different aspects of the disease and the status of disease modifying treatments in Pakistan and South Asia. MS is not as uncommon in Pakistan as it has been previously thought to be. Estimated prevalence of MS in Pakistan may be 10 per 100,000 population. Data suggests that most features of MS found in Pakistan are similar to those found in the West. from Journal of the Neurological Sciences https://ift.tt/3jVepf4
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Gut Feelings Can Be Good for Us

The more we pay attention to our internal bodily sensations, specifically gastric interoception, the more positive we feel about our bodies, a new study reports. from Neuroscience News https://ift.tt/33kyfdE
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Memory Loss Reversed or Abated in Those With Cognitive Decline

Study reports success in treating cognitive decline and memory loss associated with Alzheimer's disease with the aid of personalized precision medicine. from Neuroscience News https://ift.tt/3gg5D9a
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The effect of platelet transfusion on functional independence and mortality after antiplatelet therapy associated spontaneous intracerebral hemorrhage: A systematic review and meta-analysis

The practice of platelet transfusion to mitigate the deleterious effects of antiplatelet agents on spontaneous intracerebral hemorrhage (ICH) remains common. However, the effect of antiplatelet agents on patients with ICH is still controversial and transfusing platelets is not without risk. We performed a meta-analysis in order to determine the effect of platelet transfusion on antiplatelet agent associated ICH. from Journal of the Neurological Sciences https://ift.tt/33dnHNJ
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Homonymous hemi-macular atrophy of the ganglion cell-inner plexiform layer with preserved visual function

Homonymous hemimacular thinning of the retinal ganglion cell-inner plexiform layer (GCIPL) on optical coherence tomography (OCT) in the absence of significant visual field defects may be identified in the workup of patients with visual complaints, but the causes of this finding remain unknown. We retrospectively reviewed 1425 consecutive patients referred for neuro-ophthalmic assessment who had high quality OCT scans and reliable Humphrey 24–2 SITA-Fast testing. A total of 7 patients, 3 females and 4 males, with a mean age of 39.4 ± 10.5 years that had homonymous thinning of the OCT macular-GCIPL without significant visual field defects were included in the study. from Journal of the Neurological Sciences https://ift.tt/30g1IUp
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Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review

Congratulations Drs. Kai‐Liang Wang,  Joshua K. Wong,  Robert S. Eisinger, Christine Smith, Wei Hu,  Aparna Wagle Shukla, Christopher W. Hess, Michael S. Okun and Adolfo Ramirez‐Zamora on the publication of “Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review,” in the June issue of Neuromodulation Technology at the Neural Interface. Abstract Objective We aimed to formulate a practical clinical treatment algorithm for Holmes’s tremor (HT) by reviewing currently published clinical data. Materials and Methods We performed a systematic review of articles discussing the management of HT published between January 1990 and December 2018. We examined data from 89 patients published across 58 studies detailing the effects of pharmacological or surgical interventions on HT severity. Clinical outcomes were measured by a continuous 1‐10 ranked scale. The majority of studies addressing treatment response were case series or case reports. No randomized ...
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Why Keeping Telemedicine Options Viable for Practices is So Critical

A national shortage of neurologists has for years resulted in patients falling through the cracks, especially those with mobility issues or who live in remote areas. The broadening of telemedicine reimbursement, brought on by the COVID-19 pandemic, has served as a net for many of these previously unseen patients. We spoke to one neurologist, Dr. Elaine Jones, who shared how this is particularly helping neurology patients in one small town in Alaska. Jones has been practicing telemedicine for years. Well before the coronavirus hit, she was able to see patients remotely from an office she set up in the home she shares with her elderly parents in South Carolina. Dr. Elaine Jones “When COVID hit, it was kind of nice that I was already doing telemedicine so I didn’t have to worry about exposure and working in an ER,” Jones told us in a recent interview. For the last handful of years she has been working for SOC Telemed , serving ERs remotely across the country. Jones ran a private n...
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UF Health Shands Hospital ranked best in Florida in 2020-21 U.S. News “Best Hospitals” survey

UF Health Shands Hospital placed a remarkable nine specialties in the Top 50 of U.S. News & World Report’s 2020-21 Best Hospitals, a feat seldom achieved by the vast majority of the 5,000 hospitals around the nation analyzed in the annual U.S. News report. No other hospital in Florida placed as many medical specialties in the Top 50 nationally, underlining our position as the leader in Florida health care. Neurology and neurosurgery were rated a “high-performing” specialty, which means it ranked in the top 10% of all hospitals scored in that specialty across the United States. These rankings are a reflection of how our employees are entirely focused on giving their best every day to meet the needs of our patients. It is teamwork and this commitment to excellence that brings such national recognition to UF Health’s premier clinical care, education and research programs. We applaud you for the great efforts all of you — faculty, staff, housestaff and students — are contributing a...
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Young Kids Could Spread COVID-19 As Much As Older Children and Adults

Children younger than five with mild-to-moderate coronavirus have might higher levels of genetic materials for the virus in their noses compared to older children and adults. The findings suggest young children as able to transmit COVID-19 to the same degree as those in other age groups. from Neuroscience News https://ift.tt/3jTmQrg
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Your Brain Parasite Isn’t Making You Sick, Here’s Why

Microglia keep the Toxoplasma gondii parasite in check in the brain. Microglia release an immune molecule that recruit immune cells from the blood to control the parasite. from Neuroscience News https://ift.tt/3jUlqNb
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New Hope as Dementia Therapy Reverses Memory Loss

Activating p38gamma, a naturally protective enzyme in the brain, may help to prevent the development of Alzheimer's disease symptoms. Researchers showed the naturally protective effects of p38gamma could be harnessed to improve memory in the later stages of Alzheimer's disease. from Neuroscience News https://ift.tt/30jFCk1
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Laughter Acts as a Stress Buffer, and Even Smiling Helps

Laughing and smiling more might help to buffer against the effects of stress, researchers report. from Neuroscience News https://ift.tt/2XdFZuc
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Alzheimer’s Risk Factors May Be Measurable in Adolescents and Young Adults

Alzheimer's risk factors could be apparent as early as our teenage years, researchers reports. The risk factors disproportionately affect African Americans and include heart health problems, high cholesterol, diabetes, and insufficient quality of education. from Neuroscience News https://ift.tt/3gt6jIF
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Botox Injections May Lessen Depression

Botox injections appear to improve symptoms of depression, regardless of the injection site, a new study reports. Researchers found depression was reported 40 - 88% less often in patients treated with Botox. from Neuroscience News https://ift.tt/316Ch73
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Lead Repositioning Guided by Both Physiology and Atlas Based Targeting in Tourette Deep Brain Stimulation

Congratulations Jackson N. Cagle, Wissam Deeb , Robert S. Eisinger , Rene Molina , Enrico Opri , Marshall T. Holland,  Kelly D. Foote , Michael S. Okun , and Aysegul Gunduz on the publication of “Lead Repositioning Guided by Both Physiology and Atlas Based Targeting in Tourette Deep Brain Stimulation,” in Tremor and Other Hyperkinetic Movements. Abstract Background:  The centromedian (CM) region of the thalamus is a common target for deep brain stimulation (DBS) treatment for Tourette Syndrome (TS). However, there are currently no standard microelectrode recording or macrostimulation methods to differentiate CM thalamus from other nearby structures and nuclei. Case Report:  Here we present a case of failed conventional stereotactic targeting in TS DBS. Postoperative local field potential recordings (LFPs) showed features including beta power desynchronization during voluntary movement and thalamo-cortical phase amplitude coupling at rest. These findings suggested tha...
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Fifty Years of Magnetoencephalography

Author: Edited by Andrew C. Papanicolaou, Timothy P.L. Roberts, and James W. Wheless ISBN: 9780190935689 Binding: Hardcover Publication Date: 30 July 2020 Price: $125.00 from journals https://ift.tt/3135LCr
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How Women and Men Forgive Infidelity

Males and females view physical and emotional cheating differently. Women consider emotional affairs to be more serious, and men believe physical infidelity to be more serious generally. Researchers report if one partner feels their relationship is threatened by cheating, it is harder for them to forgive infidelity, regardless of gender. from Neuroscience News https://ift.tt/3fclQer
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Sense of Normalcy Bounces Back Fast

Following extremely stressful events, the human sense of normalcy can bounce back within a matter of weeks, a new study reports. from Neuroscience News https://ift.tt/39B7va8
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Cervicofacial Venous Malformations Are Associated with Intracranial Developmental Venous Anomalies and Dural Venous Sinus Abnormalities

Fellows’ Journal Club Sixty-three consecutive patients who presented to the authors’ institution with cervicofacial venous malformations and underwent postcontrast MR imaging were studied. Three neuroradiologists reviewed brain MRIs for the presence of developmental venous anomalies, dural venous sinus ectasia, and cavernous malformations. The prevalence of developmental venous anomalies in this patient population was compared with an age- and sex-matched control group without venous malformations. The overall presence of developmental venous anomalies in patients with venous malformations was 36.5% (23/63) compared with 7.9% (10/126) in controls. The prevalence of dural venous sinus ectasia was 9.5% (6/63) compared with 0% for controls. The authors show a significant association between cervicofacial venous malformations and cerebral developmental venous anomalies as well as between cervicofacial venous malformations and dural venous sinus abnormalities. Abstract A 5-year-old...
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High Spatiotemporal Resolution 4D Flow MRI of Intracranial Aneurysms at 7T in 10 Minutes

Editor’s Choice The authors used pseudospiral Cartesian undersampling with compressed sensing reconstruction to achieve high spatiotemporal resolution (0.5mm isotropic, ∼30 ms) in a scan time of 10 minutes. They analyzed the repeatability of accelerated 4D-flow scans and compared flow rates, stroke volume, and the pulsatility index with 2D-flow and conventional 4D-flow MR imaging in a flow phantom and 15 healthy subjects. Mean flow-rate bias compared with 2D-flow was lower for accelerated than for conventional 4D-flow MR imaging. Pulsatility index bias gave similar results. Stroke volume bias showed no difference from accelerated bias for conventional 4D-flow MR imaging. Repeatability for accelerated 4D-flow was similar to that of 2D-flow MR imaging. They conclude that highly accelerated high-spatiotemporal-resolution 4D-flow MR imaging at 7T in intracranial arteries and aneurysms provides repeatable and accurate quantitative flow values. Abstract BACKGROUND AND PURPOSE A , F...
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Stroke as a delayed manifestation of multi-organ thromboembolic disease in COVID-19 infection

Here, we report a patient with COVID-19 with delayed onset multi-vessel cerebral infarcts and systemic pro-thrombotic state and coagulopathy manifesting as acute limb ischemia and pulmonary embolism to highlight the importance of vigilant monitoring for neurologic impairment and coagulopathy in patients with severe cases of COVID-19 infection. In December 2019, a cluster of pneumonia cases emerged in Wuhan, Hubei Province; later identified as a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19). from Journal of the Neurological Sciences https://ift.tt/3g78fGm
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Exosomal TAR DNA-binding protein-43 and neurofilaments in plasma of amyotrophic lateral sclerosis patients: A longitudinal follow-up study

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease with characteristic of progressive general muscle weakness and atrophy. ALS is still lack of efficient treatment and laboratory biomarkers. In this study, we longitudinally examined ALS patients' peripheral blood to search potential biomarkers.18 ALS patients aged between 20 and 65 years were recruited in a clinical trial and longitudinal plasma samples were obtained and analyzed at baseline, 1, 3, 6 and 12 months follow up. from Journal of the Neurological Sciences https://ift.tt/335FsOH
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Bacteria in the Gut Have a Direct Line to the Brain

Sensory neurons that send signals from the intestines to the brain stem extend to the interface of areas of the intestine that are exposed to high levels of microbial compounds. Turning off the neurons, researchers observed activated neurons in the brainstem as well as activation of gut neurons that control intestinal motility. The findings shed light on the potential mechanisms behind neurological abnormalities and intestinal diseases, including IBS. from Neuroscience News https://ift.tt/3g67LjP
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Increased Attention to Sad Faces Predicts Depression Risk in Teenagers

Biased attention to sad faces increases the risk of teenagers developing depression, a new study reports. from Neuroscience News https://ift.tt/2P4HKp0
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Hugo Liepmann, Parkinson’s disease and upper limb apraxia

Congratulations Dr. Kenneth Heilman, on the publication of “ Hugo Liepmann, Parkinson’s disease and upper limb apraxia ,” in the July 21st issue of Cortex. Abstract It has now been 100 years since Hugo Liepmann, in his classic 1920 paper described limb kinetic, ideomotor, and ideational apraxia. There are now several rating scales used to assess and grade the signs and symptoms associated with Parkinson’s disease; however, none of these assesses patients for the presence of these disabling forms of upper limb apraxia. This paper, reviews the types of apraxia that can be associated with Parkinson’s disease, how they can be tested, the disabilities associated with these disorders and possible treatments. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/314hUr8
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Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study

ew drugs were confirmed to be effective in the treatments of neurological dysfunction caused by acute intracerebral hemorrhage (ICH). The present prospective clinical trial aims to evaluate the effect of mouse nerve growth factor (mNGF) on neurological function in patients with acute ICH. from Journal of the Neurological Sciences https://ift.tt/30e5rSx
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Using Artificial Intelligence to Smell the Roses

New artificial intelligence technology can accurately predict how any chemical is going to smell to humans. from Neuroscience News https://ift.tt/3jNLhWV
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Maternal Depression Increases Odds of Depression in Offspring

Adolescents and adults whose mothers experienced depression, either during pregnancy or shortly after, had a 70% increased risk of being diagnosed with depression. from Neuroscience News https://ift.tt/3hN5ESe
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Mental Fatigue of Multiple Sclerosis Linked to Inefficient Recruitment of Neural Resources

Those with MS allocate neural resources less effectively when faced with increased cognitive task demands, and this likely results in the increased mental fatigue those with the neurodegenerative disorder experience. from Neuroscience News https://ift.tt/2P4MPhq
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Your Brain on Birth Control

Oral contraceptive use is associated with blunted stress response and brain activity differences during working memory tasks in women who started using birth control during puberty. Early adulthood exposure to oral contraceptives was linked to significant structural changes in brain areas associated with memory and emotional processing. from Neuroscience News https://ift.tt/2EtWig3
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Pessimistic Outlook on Life Linked to Life Expectancy

Pessimistic people are more likely to die earlier from cardiovascular disease and other causes, but not from cancer than those who have a more optimistic outlook on life. However, optimists did not have a greater than average life expectancy. from Neuroscience News https://ift.tt/39yYm1T
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Further Evidence World Trade Center Responders Are at Risk for Dementia

First responders at the World Trade Center have reduced cortical gray matter thickness, which was consistent with neurodegenerative conditions and evidence their brain age is, on average, ten years older than those of similar ages in the general population. from Neuroscience News https://ift.tt/2BD1Bsx
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Alzheimer’s Protein in Blood Indicates Early Brain Changes

Blood samples taken from people enrolled in an Alzheimer's research study revealed higher levels of phosphorylated tau 217 that correlated with the presence of amyloid plaques. People with amyloid in their brains had up to three times more of the tau protein in their blood than those who had no evidence of amyloid accumulation. The higher levels of the protein were evident even in people with no signs of cognitive decline. from Neuroscience News https://ift.tt/2BDECxx
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Experimental Drug for Alzheimer’s May Help Children With Autism

Children suffering from a form of autism called ADNP syndrome may benefit from an experimental drug designed to treat Alzheimer's disease. from Neuroscience News https://ift.tt/39Be9NJ
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Identification of Taenia solium DNA by PCR in blood and urine samples from a tertiary care center in North India

NCC is a neglected zoonotic disease with high endemicity and disease burden. Neurocysticercosis is a frequent cause of seizures in endemic countries. Early diagnosis and therapy helps in reducing morbidity and DALYs (daily adjusted life years) lost. Definite diagnosis still relies on neuroimaging identification of scolex or by histopathological examination. Molecular method such as PCR (Polymerase Chain Reaction) is an emerging modality to supplement or complement these Gold standard methods. from Journal of the Neurological Sciences https://ift.tt/3jQyx1I
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UF neurologists create a new image of Parkinson disease

An outdated sketch from 1886 by Sir William Richard Gowers remains among the most used and viewed depictions of Parkinson disease, despite great advancements in the understanding of the neurological disorder. Now, UF neurologists  Melissa Armstrong , M.D. and  Michael S. Okun , M.D. have worked with a medical illustrator to create a new, more diverse representation of who is affected by Parkinson diesease, and how. The image was unveiled today in a new JAMA Neurology article. from Department of Neurology » College of Medicine » University of Florida https://ift.tt/2Elbvjm
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Ultra-Low Power Brain Implants Find Meaningful Signal in Grey Matter Noise

Researchers reduced the power requirements of neural interfaces while improving their accuracy by tuning into a subset of brain waves. from Neuroscience News https://ift.tt/2De3gFa
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Teaching NeuroImages: Spindle coma following cerebral herniation and pontine infarction

A 67-year-old woman presented with bilateral subdural hematomas. After hematoma evacuation, she was unresponsive with extensor posturing and preserved brainstem reflexes. MRI (figure 1) revealed extensive posterior circulation infarction including the mid-pons, thought secondary to herniation and vascular compression. EEG (figure 2) revealed an unreactive background resembling normal N2 sleep (including spindles, K-complexes, and vertex waves) for >24 hours, diagnostic of spindle coma. 1 Conditions implicated in spindle coma tend to disrupt the ascending arousal system at the brainstem and hypothalamic level, but spare the thalamus. 1,2 Underlying etiology, extent of injury, and EEG reactivity provide more prognostic insight than spindle coma alone. 1,2 from Neurology recent issues https://ift.tt/2X1Ffs0
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Parkinson disease: The long-term benefits of early use of deep brain stimulation

In their article "Deep brain stimulation in early-stage Parkinson disease: Five-year outcomes," 1 Dr. Hacker and colleagues compared 2 groups of people with Parkinson disease (PD): those who only took medication for their PD and those who combined medications with deep brain stimulation (DBS). Other studies have taken a similar approach, but this study was different because it looked at people who had early PD. Most past studies have focused only on people with moderate or advanced PD. In addition, this study looked at outcomes after 5 years. Most studies are shorter, and do not look at how people do over a long period of time. from Neurology recent issues https://ift.tt/309gmgh
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Hedonism Leads to Happiness

Pursuing hedonistic goals, such as taking time to yourself for relaxation or activities you enjoy, are essential, yet often neglected, for personal wellbeing. from Neuroscience News https://ift.tt/2Ej8Ma8
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Changes in Brain Cartilage May Explain Why Sleep Helps You Learn

Altering the structure of perineuronal nets could be a mechanism that underlies sleep-induced memory changes. from Neuroscience News https://ift.tt/2X3eUtF
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Lithium in Drinking Water Linked With Lower Suicide Rates

Study reports naturally occurring lithium in public drinking water may lower suicide rates. Researchers found that in geographical areas with high concentrations of lithium in drinking water, suicide rates were lower in the population. from Neuroscience News https://ift.tt/2OZ3ouO
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Flu and Pneumonia Vaccinations Tied to Lower Risk of Alzheimer’s

Being vaccinated against influenza was associated with a 17% reduction in Alzheimer's incidence. Pneumonia vaccinations given between the ages of 65 and 75, reduced Alzheimer's risk by up to 40%. from Neuroscience News https://ift.tt/32YxJSx
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Brain Cell Types Identified That May Push Males to Fight and Have Sex

Mouse study reveals "on-off switch" nerve cells for male mating and aggression in the amygdala. MPN signaling cells in the amygdala that communicate with the hypothalamus are associated with reproductive behavior, and VMHvL signaling cells play a critical role in aggression. from Neuroscience News https://ift.tt/3hFH1XH
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Incidental findings in peer neurological examination

Physical examination skills training is a central element of the undergraduate medical education. A frequently used approach is peer physical examination (PPE), in which medical students examine each other, or the instructor examines a student [1]. PPE avoids patient discomfort, allows additional skills practice and the recognition of normal examination features. The last point is particularly useful when learning the neurological examination, which requires intensive training for the identification of what is or not pathological [2]. from Journal of the Neurological Sciences https://ift.tt/2P2mrEN
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Article title: On the plausibility of late neuropsychiatric manifestations associated with the COVID-19 pandemic

Recognition of the association between acute and subacute different neuropsychiatric manifestations with the infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic, is progressively being recognized [1]. The potential emergence of late onset neuropsychiatric manifestations after infection with SARS-CoV-2 remains to be discussed. After the “Spanish” influenza pandemic in the 20th century, an outbreak of encephalitis lethargica (EL) [2], a neuropsychiatric disorder of possible autoimmune origin emerged occurring soon after the acute phase or at some time later [3]. from Journal of the Neurological Sciences https://ift.tt/2DcnHCo
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Low cerebrospinal fluid volume and the risk for post-lumbar puncture headache

Background:Cerebrospinal fluid (CSF) is essential for the medical workup of patients with neurological conditions as for disease-modifying clinical trials. Post- lumbar puncture (LP) headache is influenced by both operator and patient factors, including needle type and gauge, age and gender.Objectives: We aimed to assess whether CSF volume as measured in pre-procedural brain MRI, is associated with the risk of developing a post-LP headache.Methods: In total, n = 117 participants (n = 58 Parkinson's disease patients, and n = 59 healthy controls) underwent an LP and CSF collection. from Journal of the Neurological Sciences https://ift.tt/39wfMfr
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Diagnosing myasthenic crisis in SARS-CoV-2 infected patients requires adherence to appropriate criteria

With interest we read the article by Delly et al. about a 56 years old female with myasthenia gravis (MG) since 5y for which she received pyridostigmine (240 mg/d), prednisone (40 mg/d), and intravenous immunoglobulins (IVIG, 650 mg/kg within 2d every 2 weeks), and with undetermined mixed connective tissue disease for which she received chloroquine (400 mg/d), who developed myasthenic crisis with respiratory insufficiency during pneumonia due to infection with SARS-CoV-2 [1]. Though the patient received vancomycin, cefepime, and azithromycin and prednisone was increased to 80 mg/d, she lastly had to be intubated and required mechanical ventilation [1]. from Journal of the Neurological Sciences https://ift.tt/305KUPX
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As cases of Parkinson’s disease increase, community must demand funding, change

The odds of a person developing Parkinson’s disease over a lifetime are 1 in 15. It is the fastest growing neurodegenerative disease and is overtaking Alzheimer’s for the top spot. That stunning growth curve foreshadows bankruptcy for many health-care systems, said Dr. Michael S. Okun of University of Florida health, a leading international expert on Parkinson’s. He is one of four authors of the authoritative new book “Ending Parkinson’s: A Prescription for Change.” from Department of Neurology » College of Medicine » University of Florida https://ift.tt/3gNERVE
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Genetic Mutations Predispose Individuals to Severe COVID-19

Study identifies the TLR7 gene as an essential player in the immune response against coronavirus infection. from Neuroscience News https://ift.tt/39xbi88
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Narcissists Don’t Learn From Their Mistakes Because They Don’t Think They Make Any

When most people make errors, they are willing to learn from their mistakes. Those with narcissistic personality traits fail to acknowledge when they make mistakes and are thus unable to learn from errors they have made. from Neuroscience News https://ift.tt/3f2Pqmz
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Brain Thickness and Connectivity, Not Just Location, Correlates With Behavior

Cortical thickness and regional brain connectivity pay an equally important role in linking brain and behavior. from Neuroscience News https://ift.tt/3hBAuNO
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Brain Science under the Swastika

Author: Lawrence A. Zeidman ISBN: 9780198728634 Binding: Hardcover Publication Date: 26 July 2020 Price: $50.00 from journals https://ift.tt/3hyBxhx
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Is thrombolysis beneficial when time of stroke onset is unknown?

Efficacy and safety of thrombolytic therapy for stroke with unknown time of onset: a meta-analysis of observational studies. Zhu RL, Xu J, Xie CJ, Hu Y, Wang K. J Stroke Cerebrovasc Dis 2020 (Epub ahead of print). Abstract BACKGROUND: Recombinant tissue plasminogen activator (rt-PA) is one of the most effective therapies available for patients with […] via Is thrombolysis beneficial when time of stroke onset is unknown? — Neurochecklists Blog from The Neurology Lounge https://ift.tt/2D8jsHY
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Rely on Gut Feeling? How the Second Brain in Gut Communicates

Viscerofugal neurons inside the gut wall communicate to other neurons outside of the gut, near the spinal cord, to send messages to the brain. from Neuroscience News https://ift.tt/2OWKS6o
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Unique Insights Into How We Change as We Age

A study that has been on-going for thirty-five years sheds light on several transitions throughout our lifespans. from Neuroscience News https://ift.tt/3316K8O
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Regenerative plasticity of intact human skin axons

The evaluation of human epidermal innervation and its impact by disease has largely focused on rigorous immunohistochemical counts of PGP 9.5 labelled axons. In this brief and preliminary report, we expand the repertoire of epidermal axon markers to include those with an influence on their regenerative plasticity. We studied human lower limb punch skin samples with tandem analyses of their mRNA content using qRT-PCR. Normal human subjects (n = 11) and two patients with newly diagnosed CIDP were sampled with the latter undergoing serial tandem biopsies before and after 3 months of immunotherapy. from Journal of the Neurological Sciences https://ift.tt/2BywUES
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A good compilation by someone (copied)for those interested in world of neurology - - Neurology Textbooks: https://drive.google.com/open?id=0B7fZ6PPB8HPUV1FkRzZxcWF6dm8 - Neurology Boards: https://drive.google.com/open?id=0B7fZ6PPB8HPUc3d6dmlTZ21jVlE - Neurology Emergency: https://drive.google.com/open?id=0B7fZ6PPB8HPUY2lZTVA3dGF1bkU - Neurocritical Care: https://drive.google.com/open?id=0B7fZ6PPB8HPUb1ltVHctNE5CS28 - Neuroradiology: https://drive.google.com/open?id=0B7fZ6PPB8HPUbHBQQ28td0thMU0 - Neurointervention: https://drive.google.com/open?id=0B7fZ6PPB8HPURFlvWGZUZi1XTVU - Neurophysiology: https://drive.google.com/open?id=0B7fZ6PPB8HPUZmI0LUNHVG1SbFk - Neuroscience: https://drive.google.com/open?id=1mRCMadM4mYhEuUDrBvR_0YpdFtVDsp9x - Neuroanatomy: https://drive.google.com/open?id=0B7fZ6PPB8HPUcjc3NUEyUkhCOHM Neurology Specialities - Epilepsy: https://drive.google.com/open?id=0B7fZ6PPB8HPUUUxIdEloWUFUZ2M - Headache: https://drive.google....
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