NEURO

Researchers report exposure to common pesticides, such as PCBs, can accelerate the progression of ALS. from Neuroscience News Updates https://ift.tt/2EDF6lM

Study reveals women have higher activation in sensory areas of the brain associated with pain compared to males when witnessing another person suffering. from Neuroscience News Updates https://ift.tt/2Vt6Krj

Researchers use nanotech to enhance vision in mice, enabling them to see infrared light as well as visible light. from Neuroscience News Updates https://ift.tt/2T9olYL

Are you up-to-date on recent guidelines for the management of agitation, anxiety, apathy, psychosis, and sleep disorders in patients with Huntington disease? Take this brief quiz to find out. from Front page feed https://ift.tt/2VqVb3O

Researchers report younger people are more likely to die from alcohol consumption, where as older people are more likely to see health benefits from moderate drinking. from Neuroscience News Updates https://ift.tt/2tGSGyB

A new study of the genetic data from over 94,000 people with Alzheimer's has identified five new risk genes, as well as confirmed 20 other known genes in the disease. from Neuroscience News Updates https://ift.tt/2H6pqt6

CaImAn, a new open source software, allows for real time tracking of the location and activity of neurons, researchers report. from Neuroscience News Updates https://ift.tt/2H8tfOc

Researchers suggest blind and sighted people experience visual phenomena differently, but share a common understanding of them. from Neuroscience News Updates https://ift.tt/2tHLnql

A new study reveals that, on some health measures, yo-yo sleep schedules may be worse for you. Researchers report sleeping in on weekends can shift circadian rhythm, making it more difficult to fall asleep on Sunday nights, and whole body insulin sensitivity worsened by up to 27%. from Neuroscience News Updates https://ift.tt/2BXkMKu

VanRyzin et al. demonstrate that microglia in the developing amygdala engulf and kill otherwise viable newborn astrocytes, establishing sex differences in social circuits. This process, which depends on gonadal hormones and endocannabinoid signaling, promotes juvenile play by males. from journals https://ift.tt/2GRzyGR

No abstract available from Current Opinion in Neurology - Current Issue https://ift.tt/2H5D6V7

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Purpose of review Recent publications point to an increasingly important role of variants in genes encoding GABAA receptor subunits associated with both common and rare forms of epilepsies. The aim of this review is to give an overview of the current clinical phenotypes, genetic findings and pathophysiological mechanisms related to GABAA receptor variants. Recent findings Early work showed that inherited variants in GABRG2 and GABRA1 cause relatively mild forms of monogenic epilepsies in large families. More recent studies have revealed that de novo variants in several GABAA receptor genes cause severe developmental and epileptic encephalopathies, inherited variants cause remarkably variable phenotypes within the same pedigrees ranging from asymptomatic carriers to developmental and epileptic encephalopathies, and variants in all GABAA receptor genes are enriched in common forms of epilepsy, namely rolandic epilepsy and genetic generalized epilepsy. Analyses from cellular expression sy...

Purpose of review There has been rapid progress in defining novel causative gene variants responsible for a large spectrum of human epilepsy syndromes and subtypes. Of particular interest is the discovery that somatic mutations, for example, noninherited mutations occurring in neuroglial progenitor cells during embryonic brain development, are highly linked to malformations of cortical development (MCD) such as focal cortical dysplasia (FCD) type II and hemimegalencephaly. Recent findings Somatic gene variants have been identified in genes encoding regulatory proteins within the mechanistic target of rapamycin (mTOR) signaling cascade and have thus comprised the group classified as mTORopathies. FCD II and hemimegalencephaly often result from mutations in identical genes suggesting that these are spectrum disorders. An exciting recent development has been the identification of somatic mutations causing both FCD Ia and nonlesional neocortical epilepsy. Summary Defining somatic gene muta...

Purpose of review There is need for automated seizure detection using mobile or wearable devices, for objective seizure documentation and decreasing morbidity and mortality associated with seizures. Due to technological development, a high number of articles have addressed non-electroencephalography (EEG)-based seizure detection. However, the quality of study-design and reporting is extremely heterogeneous. We aimed at giving the reader a clear picture on the current state of seizure detection, describing the level of evidence behind the various devices. Recent findings Fifteen studies of phase-2 or above, demonstrated that non-EEG-based devices detected generalized tonic–clonic seizures (GTCS) with high sensitivity (≥90%) and low false alarm rate (FAR) (down to 0.2/day). We found limited evidence for detection of motor seizures other than GTCS, mostly from subgroups in larger studies, targeting GTCS. There is little evidence for non-EEG-based detection of nonmotor seizures: sensitivit...

Purpose of review The current review updates our knowledge regarding sudden unexpected death in epilepsy patient (SUDEP) risks, risk factors, and investigations of putative biomarkers based on suspected mechanisms of SUDEP. Recent findings The overall incidence of SUDEP in adults with epilepsy is 1.2/1000 patient-years, with surprisingly comparable figures in children in recently published population-based studies. This risk was found to decrease over time in several cohorts at a rate of −7% per year, for unknown reasons. Well established risk factors include frequency of generalized tonic–clonic seizures, while adding antiepileptic treatment, nocturnal supervision and use of nocturnal listening device appear to be protective. In contrast, recent data failed to demonstrate the predictive value of heart rate variability, periictal cardiorespiratory dysfunction, and postictal generalized electroencephalography suppression. Preliminary findings suggest that brainstem and thalamic atrophy ...

Purpose of review Precise localization of the epileptogenic zone is imperative for the success of resective surgery of drug-resistant epileptic patients. To decrease the number of surgical failures, clinical research has been focusing on finding new biomarkers. For the past decades, high-frequency oscillations (HFOs, 80–500 Hz) have ousted interictal spikes – the classical interictal marker – from the research spotlight. Many studies have claimed that HFOs were more linked to epileptogenicity than spikes. This present review aims at refining this statement in light of recent studies. Recent findings Analysis based on single-patient characteristics has not been able to determine which of HFOs or spikes were better marker of epileptogenic tissues. Physiological HFOs are one of the main obstacles to translate HFOs to clinical practice as separating them from pathological HFOs remains a challenge. Fast ripples (a subgroup of HFOs, 250–500 Hz) which are mostly pathological are not found in ...

Purpose of review To review the history, pharmacology, and clinical science of cannabidiol (CBD) in the treatment of epilepsy. Recent findings Phase III randomized controlled trials and prospective open label trials have provided efficacy and safety data for the use of CBD in pediatric onset severe epilepsies. The product that was studied in the vast majority of these published trials, Epidiolex (>99% of CBD and <0.10% Δ9-tetrahydrocannabinol (THC); GW pharmaceuticals, Cambridge, UK), has now been FDA approved based on this published data. Summary Identification of CBD, Δ9-THC, and the endocannabinoid system in the mid-20th century has led to advancement of cannabis-based therapies for epilepsy. Based on clinical trial data, Epidiolex is the first CBD medication approved by a national regulatory agency (US Food and Drug Administration for Dravet and Lennox Gastaut syndrome; European Medicines Agency for Lennox Gastaut syndrome). Approval of CBD as a treatment for these rare and s...

Purpose of review Behavioral intervention describes multiple modalities of treatments which are of increasing interest in epilepsy. This review addresses recent behavioral clinical trials in epilepsy including cognitive behavioral therapy (CBT), mindfulness, progressive muscle relaxation (PMR), and self-management. Results and conclusions from updated Cochrane reviews and the recent International League Against Epilepsy Psychology task force are presented. Recent findings Two recent large randomized controlled trials (mindfulness and progressive muscle relaxation) reported improved seizure frequency with behavioral treatments. In both studies, participants in both the active and the attentional control arms showed significant seizure reduction, whereas quality of life and stress reduction were better noted in the active arms. Additional behavioral modalities have reported improved seizure control including yoga, bio/neurofeedback, and music therapy. Significant improvements in multiple...

Purpose of review MRI-guided stereotactic laser interstitial thermal therapy (LiTT) has been utilized in the surgical treatment of discrete, small epileptogenic lesions. This review summarizes the current literature and addresses the clinical application of this technique. Recent findings LiTT has the potential to reduce the morbidity and discomfort of epilepsy surgery. Review of data from retrospective, uncontrolled studies suggests that LiTT may offer benefit when treating drug-resistant epilepsy because of mesial temporal sclerosis, hypothalamic hamartoma, cavernous hemangioma, and small cortical dysplasias and malformations. It is now being offered as initial therapy in place of anterior temporal lobectomy in many centers, and a prospective study is underway to compare it with historical temporal lobectomy reports. Summary LiTT appears promising and has potential for reduced morbidity and improved tolerability compared with open surgery. Studies must be done to compare efficacy and...

Purpose of review We review data on the comparative teratogenicity of antiepileptic drugs (AEDs), focusing on major congenital malformations (MCMs), intrauterine growth restriction, impaired cognitive development, and behavioral adverse effects following prenatal exposure. Recent findings Prospective registries and meta-analyses have better defined the risk of MCMs in offspring exposed to individual AEDs at different dose levels. Valproate is the drug with the highest risk, whereas prevalence of MCMs is lowest with lamotrigine, levetiracetam, and oxcarbazepine. For valproate, phenobarbital, phenytoin, carbamazepine, and lamotrigine, the risk of MCMs is dose-dependent. Prenatal exposure to valproate has also been confirmed to cause an increased risk of cognitive impairments and autistic traits. In a population-based study, the risk of AED-induced autistic traits was attenuated by periconceptional folate supplementation. Summary The risk of adverse fetal effects differs in relation to th...

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Purpose of review Knowledge on primary progressive aphasia (PPA) has expanded rapidly in the past few decades. Clinical characteristics, neuroimaging correlates, and neuropathological features of PPA are better delineated. This facilitates scientific studies on the disease pathophysiology and allows speech and language therapy to be more precisely targeted. This review article begins with a summary of the current understanding of PPA and discusses how PPA can serve as a model to promote scientific discovery in neurodegenerative diseases. Recent findings Studies on the different variants of PPA have demonstrated the high compatibility between clinical presentations and neuroimaging features, and in turn, enhances the understanding of speech and language neuroanatomy. In addition to the traditional approach of lesion-based or voxel-based mapping, scientists have also adopted functional connectivity and network topology approaches that permits a more multidimensional understanding of neur...

Purpose of review This study, taking the example of Alzheimer's and Parkinson's diseases, presents the experimental and human data that support the hypothesis that Aβ, tau, and α-synuclein may seed and propagate the pathology and consider the potential clinical consequences. Recent findings Aβ aggregates transmit Aβ pathology to experimental animals. Interhuman transmission of Aβ pathology has also been observed in iatrogenic Creutzfeldt–Jakob disease, or after dural graft. Tau aggregates also transmit the pathology to mice when injected in the brain and propagates along neuronal pathways. Evidence of interhuman transmission is weak. Finally α-synuclein aggregates, when injected in specific areas of the brain may recapitulate Lewy pathology of Parkinson's disease but there is currently no hint of human to human transmission. Summary Since the first evidence that at least Aβ pathology of Alzheimer's disease could be transmitted to the animal, data have accumulated indica...

Purpose of review Over the last year, research into the immunological and inflammatory signatures of frontotemporal lobar degeneration (FTLD) has accelerated greatly. Herein, we highlight recently proposed roles of brain-resident microglia as well as peripheral myeloid cells in frontotemporal dementia (FTD)-spectrum disorders. Recent findings Recent unbiased genetic, transcriptomic, and proteomic surveys using human data confirm significantly altered immune-function genes as well as transcript and protein modules associated with inflammatory and immune function. Beyond human studies, novel animal models indicate important roles for both microglia and monocytes, and central involvement of genes such as Trem2, Apoe, and Tbk1. Summary The importance of neuroinflammatory activity in FTD pathophysiology is unambiguous, but whether this activity is primarily beneficial or detrimental remains unclear, with variable results reported for distinct disease paradigms. Going forward, it will be cru...

Purpose of review The purpose of this review is to provide an update on comorbidities in neurodegenerative conditions. The term comorbidity is used here to distinguish cases with overlapping pathogenic mechanisms, which includes combinations of neurodegenerative proteinopathies from cases with multimorbidity, which is defined as concomitant brain and systemic disorders with different pathogenic mechanisms. Recent findings Comorbid proteinopathies are more frequent in both sporadic and hereditary neurodegenerative diseases than previously assumed. The most frequent additional proteinopathies are related to Alzheimer's disease, Lewy body disorder, and limbic predominant transactive response DNA-binding protein 43 proteinopathy, however, different forms of tau pathologies are also increasingly recognized. In addition to ageing, synergistic interaction of proteins, common disease pathways, and the influence of genetic variations are discussed as possible pathogenic players. Summary Com...

Purpose of review Alzheimer's disease is a progressive neurodegenerative disease without effective pharmacological treatment. Noninvasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), are increasingly being investigated for their potential to ameliorate the symptoms of Alzheimer's disease and related dementias (ADRD). Recent findings A comprehensive literature review for primary research reports that investigated the ability of TMS/tES to improve cognition in ADRD patients yielded a total of 20 reports since 2016. Eight studies used repetitive TMS and 12 used transcranial direct current stimulation, the most common form of tES. Eight of the studies combined NIBS with cognitive training. Promising results should encourage continued investigation, however there is currently insufficient evidence to support widespread adoption of NIBS-based clinical treatments for ADRD. Summary NIBS re...

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At Public Books , our editorial staff and contributors are hard at work to provide readers with thought-provoking articles. But when the workday is done, what is ... The post On Our Nightstands: February 2019 appeared first on Public Books . from Public Books https://ift.tt/2tHbzBx

The UF Department of Neurology and the Epilepsy Division are delighted to announce the inaugural Wilder Center for Epilepsy Research update evening on Thursday, March 21, 2019. The event will be held at the McKnight Brain Institute, 6-9 pm. Please mark your calendars to save the date! The Wilder update evening is the first of an annual event series that encourages epilepsy-interested clinicians and neuroscientists at UF to network, and for our annual visiting professor to get to know the UF epilepsy community. This year, we have the honor of hosting Dr. Patrick Chauvel (Marseilles, France/Cleveland Clinic) as Wilder Visiting Professor. The program includes a research blitz by UF investigators and a lecture by Dr. Chauvel, and all attendees are invited to a wine reception and buffet dinner afterwards. We hope to see you on Thursday March 21! PROGRAM 6:10-7:00 pm: Dynamic methods for epilepsy MRI : Giri Kalamangalam, MD (Neurology) & Tom Mareci, PhD (AMRIS) EEG synchroni...

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A new study contradicts the popular belief that listening to music can help boost creativity. Researchers found people who listened to background music showed a significant impairment in the ability to complete tasks that tested verbal creativity. from Neuroscience News Updates https://ift.tt/2tDEuq4

A new study reports babies' brains are sensitive to different emotional tones they hear in voices. Researchers suggest maternal interactions may help to shape the same brain region adults use for emotional processing. from Neuroscience News Updates https://ift.tt/2H2ajRr

A new study reports those with alcohol addiction who also smoke may be at an increased risk of neural damage. The study revealed higher levels of oxidative stress in the hippocampus, and a a decrease in neurotrophic factor in the striatum and frontal cortex in rats exposed to both alcohol and tobacco. from Neuroscience News Updates https://ift.tt/2tKN5al

Researchers report EEG technology has the ability to study activity of areas deep inside the brain, such as the thalamus and nucleus accumbens. The findings will help shed new light on disorders that affect these brain regions, such as Parkinson's disease and OCD. from Neuroscience News Updates https://ift.tt/2H2ahZP

Antiplatelet therapies for secondary prevention of ischemic stroke or transient ischemic attack (TIA) is a highly active research topic with five critical drugs obtained by visual analysis. We aimed to compare and rank multiple antiplatelet therapies using a network meta-analysis. from Journal of the Neurological Sciences https://ift.tt/2H61KVx

Zimmerman et al. define distinct neurotransmitter and circuit mechanisms that gate the flow of tactile sensory information from the periphery into the spinal cord and characterize their roles in tactile sensitivity and behaviors. from journals https://ift.tt/2VuSZbR

Mann et al. describe an optogenetic technique to generate neurotoxic TDP-43 assemblies found in ALS/FTD patient neurons. They show that aberrant phase transitions of TDP-43 are driven by its RNA binding status and develop an approach to prevent this neurotoxic process. from journals https://ift.tt/2EAO7ME

Researchers have identified the structure of the human type 2 cannabinoid receptor. The findings, researchers say, can help in the development of new treatments for inflammatory and neurodegenerative diseases. from Neuroscience News Updates https://ift.tt/2tDwxBe

Study reinforces and explains the links between sleep deprivation and neurodegenerative diseases, researchers say. from Neuroscience News Updates https://ift.tt/2XuohB6

Researchers have identified the first common genetic risk variants for ASD. The study, which also reveals specific genetics differences in clinical subgroups of autism, may help in providing more precise diagnoses for those on the autism spectrum. from Neuroscience News Updates https://ift.tt/2SyGjys

The qualitative sociologist T. L. Taylor is a professor of Comparative Media Studies at MIT and cofounder and director of research for AnyKey, an organization dedicated to supporting and developing fair and inclusive esports. She explores the interrelations of culture and technology in online leisure environments, writing in a clear style and with an evocative voice about gender, inclusivity, and... The post Public Thinker: T. L. Taylor on Gamergate, Live-Streaming, and Esports appeared first on Public Books . from Public Books https://ift.tt/2IP37L4

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Neurochecklists is currently a web-based app… But it will soon be a downloadable app. However, you don’t have to wait until then… You can use it as a smartphone app right now. Just follow our easy 3-step process… *** First step: open http://www.neurochecklists.com on your phone *** Second step: click on the highlighted ‘burger’ *** […] via How to use neurochecklists as a smartphone app — Neurochecklists Updates from The Neurology Lounge https://ift.tt/2H7qJYD

Guo et al. investigated the association between hemoglobin at acute phase and clinical outcomes in patients with ischemic stroke [1]. The authors selected major disability and death at 3 months as the primary outcomes after stroke onset and events that were separately evaluated as the secondary outcomes. Adjusted odds ratios (ORs) (95% confidence intervals [CIs]) of the highest quartile of hemoglobin against the lowest quartile for the primary outcomes, major disability and death, were 1.38 (1.03–1.86), 1.49 (1.11–1.99), and 0.79 (0.41–1.52), respectively. from Journal of the Neurological Sciences https://ift.tt/2T42SjE

We are grateful to Tomoyuki Kawada for the interest in our article—“Hemoglobin level and three-month clinical outcomes among ischemic stroke patients with elevated systolic blood pressure” [1]. It makes sense to involve peer scientists in the extensive discussions on our findings. The aim of our study was to investigate the association between hemoglobin and prognosis of ischemic stroke among patients from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). from Journal of the Neurological Sciences https://ift.tt/2Edi9V5

Does early initiation of levodopa delay disease progression? Dutch researchers sought to confirm a neuroprotective effect suggested by a previous trial. from Front page feed https://ift.tt/2Uca8Xm

Researchers report they have identified biomarkers of Alzheimer's disease in spinal fluid samples of a significant number of older patients hospitalized as a result of hip fractures. The study suggests neural alterations that lead to poor balance in older people may signify an increased risk of falls that result in hip fractures, and Alzheimer's disease. Researchers suggest the hip fracture, therefore, may serve as an early sign of Alzheimer's in older patients. from Neuroscience News Updates https://ift.tt/2Eh7Waf

Researchers report children who grow up surrounded by green space have a 55% reduced risk of developing a mental health disorder as they age. from Neuroscience News Updates https://ift.tt/2GKBeBT

A new study sheds light on how our sense of smell is affected by the decrease of neurons in our noses as we age. from Neuroscience News Updates https://ift.tt/2NwgspY

A new study challenges the assumption of many scientists, that the most active neurons involved in complex activity are also the most important in controlling behavior. from Neuroscience News Updates https://ift.tt/2GJKdDv

Study reveals context is essential for reading people's emotions. from Neuroscience News Updates https://ift.tt/2H2xESZ

In children with autism, the sound of their mom's voice creates a weaker brain response than in their peers not on the autism spectrum, a new study reports. from Neuroscience News Updates https://ift.tt/2tNxwz3

A simple screening test may help identify those at risk. from Front page feed https://ift.tt/2EdwZep

Animals engage in local search behavior after recent encounters with food-related sensory cues. López-Cruz et al. show that parallel chemosensory or mechanosensory circuits can independently trigger local search after food removal in C. elegans, each using a similar glutamate receptor module. from journals https://ift.tt/2TjAB8i

Adult neurogenesis persists in mammals. Ortiz-Álvarez et al. analyze the clonal relationship among ependymal cells and B1 astrocytes, which together compose the adult neurogenic niche. They show that their proportion is tuned by the DNA replication regulators Geminin and GemC1. from journals https://ift.tt/2IEdUr5

A new study reveals we are consciously aware of and automatically attend to our own face, even when we are not aware of it. from Neuroscience News Updates https://ift.tt/2SpkvFy

Researchers report obesity may be a result of reduced activity in the prefrontal cortex, which can influence self control and predispose a person to overeating. from Neuroscience News Updates https://ift.tt/2XmqsXH

Contrary to popular belief, developmental dyslexia is not caused by a structural dysfunction in the cerebral cortex, researchers report. A new study reveals developmental dyslexia is the result of a decrease in white matter connectivity between the mPT and MGB. from Neuroscience News Updates https://ift.tt/2T0byI4

A new study links prenatal smoking with a significantly increased risk of a child developing ADHD later in life. The study found higher cotinine levels in the mother's blood during pregnancy increased the risk of her child being diagnosed with ADHD three fold. from Neuroscience News Updates https://ift.tt/2T2wYUE

We are excited to share with you our 2018 national rankings, based on our combined NIH grant portfolio. Among 52 ranked neuroscience programs, we now rank #7 with our combined Neurology and Neuroscience grant portfolio of nearly 19 million dollars. We now rank number #2 among public universities. This outstanding record is the result of collaborative research excellence, a lot of hard work and tremendous dedication. This was a team effort and everyone contributed including grant support staff, other staff, faculty and our outstanding educational programs. Congratulations and thank  you for your efforts in advancing the national visibility of our UF-COM neuro research program.  Best wishes for continued success in your research programs! To see the full ranking list click here! from Department of Neurology https://ift.tt/2NvQpiG

If two features define contemporary capitalism, they are first the tendency of each individual to increasingly bear alone the risks associated with living in a market society, and second the enmeshment of individuals in a totalizing system of surveillance constructed from our proliferating personal data. Two remarkable recent books demonstrate that these apparently novel features of 21st-century... The post Bearing Risks and Being Watched appeared first on Public Books . from Public Books https://ift.tt/2Xmamxf

A couple of weeks ago we shared a post with you showing what a good fit content marketing is for physicians. It is one of the few forms of marketing that is patient-focused. You can read more about that in that post, Content Marketing: A Solution to the Divide Between Running a Business and the Hippocratic Oath? . Some questions may come up when you read that article and start thinking about marketing your practice: Who has the time? and How much is this going to cost me? Many neurologists have a hard enough time keeping up with their patient load, paying back student loans and trying to make a decent living besides. Our goal here at Neurology Insights is to provide benefit to neurologists and physiatrists. Since we do that in the form of content, (i.e. informational blog posts and newsletters), we thought we’d share our resources and create some content that you could share with your patients: a patient-focused monthly newsletter . This monthly unbranded newsletter is a free re...

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Coupling machine learning with brain scans, researchers reveal how people understand objects in our world. from Neuroscience News Updates https://ift.tt/2SoVIBC

A new study reports genetics, in addition to environmental factors, influence morals and some personal behaviors in adults. from Neuroscience News Updates https://ift.tt/2XnNrla

A new study reports human fat cells have their own internal clocks and circadian rhythms which affect metabolic functions. from Neuroscience News Updates https://ift.tt/2Sr1Wkl

By optimizing neurons with CRISPR gene editing technology, researchers will have new ways to study genetic influences on brain health and disease, a new study reports. from Neuroscience News Updates https://ift.tt/2XkkG8O

Spending 20 minutes in an urban park helps to increase emotional well being, regardless of whether or not a person is participating in exercise, a new study reports. from Neuroscience News Updates https://ift.tt/2U7LreH

Researchers report adolescent rats exposed to high fructose corn syrup in their diets were more prone to experience symptoms associated with bipolar disorder. from Neuroscience News Updates https://ift.tt/2BPULNa