Mann et al. describe an optogenetic technique to generate neurotoxic TDP-43 assemblies found in ALS/FTD patient neurons. They show that aberrant phase transitions of TDP-43 are driven by its RNA binding status and develop an approach to prevent this neurotoxic process.
from journals https://ift.tt/2EAO7ME
from journals https://ift.tt/2EAO7ME
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