NEURO

The disease concept of Neuromyelitis Optica Spectrum Disorders(NMOSD) has undergone a significant change over the last two decades including the detection of Myelin Oligodendrocyte Glycoprotein(MOG) antibody in patients who are seronegative for aquaporin-4 antibody. Aquaporin-4 antibody positive NMOSD is now regarded as an immune astrocytopathy. Conversely, MOG antibody associated disease is known to target myelin rather than astrocytes, leading to an NMOSD syndrome with distinct clinical and radiological features. from Journal of the Neurological Sciences https://ift.tt/3eMZpOg

Using electrical acupuncture, Liu et al. show how electrical stimulation of primary somatosensory neurons at different body regions can tap into discreet autonomic circuits and, depending on the parameters, initiate either a pro- or anti-inflammatory response. from journals https://ift.tt/3nfwtl6

Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14. from journals https://ift.tt/35liHHx

We integrate information from multiple sensory modalities and from ongoing plans to construct a perception of the world. In this issue of Neuron, Bouvier et al. (2020) and Guitchounts et al. (2020) examine the detailed circuitry that supports a flexible integration of head and visual signals in rodent primary visual cortex. from journals https://ift.tt/38ynBms

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from Neurology : nature.com subject feeds https://ift.tt/2K1gVDf