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Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of “probable PLS”

Primary lateral sclerosis is a rare neurodegenerative disorder of the upper motor neurons. Diagnostic criteria have changed considerably over the years, and the recent consensus criteria introduced ‘probable PLS’ for patients with a symptom duration of 2–4 years. The objective of this study is the systematic evaluation of clinical and neuroimaging characteristics in early PLS by studying a group of ‘probable PLS patients’ in comparison to a cohort of established PLS patients. from Journal of the Neurological Sciences https://ift.tt/3g04DWO
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Neanderthals May Have Had a Lower Threshold for Pain

Genomic research finds those who inherited a special ion channel from Neanderthals experience more pain. from Neuroscience News https://ift.tt/2WP8zlz
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Age Differences in How the Brain Perceives and Remembers

Scene selective cortical regions are more sensitive to age than face-selective regions when it comes to memory and perception. from Neuroscience News https://ift.tt/3fUV23x
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Antibiotics Disrupt Development of the ‘Social Brain’ in Mice

Early-life exposure to antibiotics may impact brain signaling pathways associated with social behavior and pain regulation. Young mice treated with antibiotics had reduced expression of receptors that mediate endorphin, oxytocin, and vasopressin signaling in the frontal cortex. from Neuroscience News https://ift.tt/30K53u1
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Mysterious Brain Structure Sheds Light on Addiction

A new study reveals the role the claustrum plays in cocaine addiction. Inhibiting claustral neurons prevented behavioral responses to cocaine in mouse models of addiction. from Neuroscience News https://ift.tt/2OStmjS
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