Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of “probable PLS”

Primary lateral sclerosis is a rare neurodegenerative disorder of the upper motor neurons. Diagnostic criteria have changed considerably over the years, and the recent consensus criteria introduced ‘probable PLS’ for patients with a symptom duration of 2–4 years. The objective of this study is the systematic evaluation of clinical and neuroimaging characteristics in early PLS by studying a group of ‘probable PLS patients’ in comparison to a cohort of established PLS patients.

from Journal of the Neurological Sciences https://ift.tt/3g04DWO