NEURO

This cross-sectional study investigates whether rapid eye movement sleep is associated with greater risk of mortality in 2 independent cohorts and explores whether another sleep stage could be driving these findings. from journals https://ift.tt/31WvaQi

This Viewpoint discusses ways to reduce overtriage for patients with neurologic disease and finding ways to care for patients at a distance during the coronavirus disease 2019 pandemic. from journals https://ift.tt/31rUvBr

While the field of Alzheimer disease (AD) continues to evaluate therapeutic regimens that begin decades before clinical symptoms, results from Oveisgharan et al reported in this issue of JAMA Neurology add to a growing body of evidence suggesting that modifiable lifestyle factors in childhood may provide some protection against disease. In 1996, Snowdon et al published data from the Nun Study highlighting that early-life linguistic ability was strongly associated with late-life cognitive decline and AD neuropathology. This transformative work demonstrated that in a largely homogenous sample with shared environmental risk factors, early-life cognitive ability modified risk for age-related disease. Oveisgharan et al dramatically extend those seminal findings by leveraging the rich cognitive, clinical, and neuropathological data from the Rush Memory and Aging Project, a prospective, community-based longitudinal cohort study of the greater Chicago, Illinois, area. The research strengthens

This cohort study compares the rate of ischemic stroke among patients with COVID-19 vs patients with influenza in 2 hospitals in New York City, New York. from journals https://ift.tt/2VJbMT7

This case series presents the clinical findings of 4 children who experienced neurological manifestations of coronavirus disease 2019. from journals https://ift.tt/31BDrZT

This cohort study examines the association of early-life cognitive enrichment with late-life Alzheimer disease and other common dementia-related pathological changes in an autopsy sample. from journals https://ift.tt/2AeAH9z

Author: Edited by Professor John N. Wood ISBN: 9780190860509 Binding: Hardcover Publication Date: 01 July 2020 Price: $230.00 from journals https://ift.tt/38hstdB

Author: Edited by Hawley Montgomery-Downs ISBN: 9780190923259 Binding: Paperback Publication Date: 30 June 2020 Price: $60.00 from journals https://ift.tt/3dM2YlI

This cohort study describes the clinical characteristics and outcomes in patients with multiple sclerosis who contract COVID-19 and identifies factors associated with COVID-19 severity. from journals https://ift.tt/2Nw682l

This randomized clinical trial examines the safety, efficacy, and feasibility of intranasal insulin for the treatment of persons with mild cognitive impairment and Alzheimer disease dementia. from journals https://ift.tt/2AYiRrP

In this issue of Neuron, Issler et al. (2020) have identified the neuronal, long intergenic noncoding RNA LINC00473 as a potential molecular risk factor for the increased susceptibility for depression in females. from journals https://ift.tt/3fBmnXY

Noxious stimuli evoke a range of acute and long-lasting sensations, emotions, and behaviors. In this issue of Neuron, Chiang et al. (2020) demonstrate that parallel outputs from the lateral parabrachial nucleus arise from specific cell types with distinct functions in pain. from journals https://ift.tt/2V9i4LJ

Animals associate different odors with good and bad memories. This memory formation requires high neuronal plasticity. In this issue of Neuron, Bilz et al. (2020) demonstrate that associative learning modulates individual synaptic boutons of the intrinsic neurons of the memory center of Drosophila. from journals https://ift.tt/3ebClaQ

Astrocytes are heterogeneous controlling numerous aspects of brain function. In this issue of Neuron, Huang et al. (2020) uncover a novel role of NFIA, which regulates unique properties of adult hippocampal astrocytes via region-specific DNA binding, thereby modulating the plasticity of local circuits. from journals https://ift.tt/2Y9KpDr

Currently available biomarkers for Alzheimer’s disease are of limited availability due to high costs and perceived invasiveness. New studies reveal that Alzheimer’s pathologies now can be reliably quantified in vivo using regular blood tests. from journals https://ift.tt/30OYZlk

In a candid interview with Neuron, Nikos K. Logothetis shares memories about his rich scientific past and argues about the importance of animal research and the role of science in society. He also talks about his new job and future plans as co-director of the International Center for Primate Brain Research in Shanghai. from journals https://ift.tt/2zECBju

Reference lists of neuroscience articles show marked gender imbalances. To mitigate this disparity and realize an equitable future, Dworkin et al. discuss relevant ethical considerations and offer practical recommendations to trainees, senior scientists, laboratory heads, editors, reviewers, mentors, and instructors. from journals https://ift.tt/2YPD6jw

With social distancing and uncertainty about the complete re-opening of laboratories and campuses, there is a pressing need for a more flexible educational experience. Seizing this opportunity to integrate active learning into adaptive curricula can fast-forward neuroscience education at every level. from journals https://ift.tt/3deojUu

Cho and Hetzer discuss recent studies that have established the nuclear pore complex as a key regulator of transcription control of cell identity genes and have linked its functional decline to premature, physiological, and pathological aging. from journals https://ift.tt/2UTPTQG

(Neuron 106, 188–198.e1–e5; April 8, 2020) from journals https://ift.tt/30NtN6d