Skip to main content

Automated MRI Classification in Progressive Supranuclear Palsy: a Large International Cohort Study

Congratulations Dr. Nikolaus McFarland on the publication of “Automated MRI Classification in Progressive Supranuclear Palsy: a Large International Cohort Study,” in the February issue of Movement Disorders.

 

Abstract

Background

The Magnetic Resonance Parkinsonism Index is listed as one of the most reliable imaging morphometric markers for diagnosis of progressive supranuclear palsy (PSP). However, the use of this index in diagnostic workup has been limited until now by the low generalizability of published results because of small monocentric patient cohorts, the lack of data validation in independent patient series, and manual measurements used for index calculation. The objectives of this study were to investigate the generalizability of Magnetic Resonance Parkinsonism Index performance validating previously established cutoff values in a large international cohort of PSP patients subclassified into PSP–Richardson’s syndrome and PSP‐parkinsonism and to standardize the use of the automated Magnetic Resonance Parkinsonism Index by providing a web‐based platform to obtain homogenous measures around the world.

Methods

In a retrospective international multicenter study, a total of 173 PSP patients and 483 non‐PSP participants were enrolled. A web‐based platform (https://mrpi.unicz.it) was used to calculate automated Magnetic Resonance Parkinsonism Index values.

Results

Magnetic Resonance Parkinsonism Index values showed optimal performance in differentiating PSP–Richardson’s syndrome and PSP‐parkinsonism patients from non‐PSP participants (93.6% and 86.5% of accuracy, respectively). The Magnetic Resonance Parkinsonism Index was also able to differentiate PSP–Richardson’s syndrome and PSP‐parkinsonism patients in an early stage of the disease from non‐PSP participants (90.1% and 85.9%, respectively). The web‐based platform provided the automated Magnetic Resonance Parkinsonism Index calculation in 94% of cases.

Conclusions

Our study provides the first evidence on the generalizability of automated Magnetic Resonance Parkinsonism Index measures in a large international cohort of PSP–Richardson’s syndrome and PSP‐parkinsonism patients. The web‐based platform enables widespread applicability of the automated Magnetic Resonance Parkinsonism Index to different clinical and research settings. © 2020 International Parkinson and Movement Disorder Society



from Department of Neurology » College of Medicine » University of Florida https://ift.tt/33NJ5HA

Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

Menopause Symptoms Reduced by Cold Water Swimming

Cold water swimming significantly eases menopausal symptoms. Surveying 1114 women, with 785 experiencing menopause, researchers found improvements in anxiety, mood swings, low mood, and hot flushes among participants. from Neuroscience News https://ift.tt/9AqHsEa
Post a Comment
Read more

UPI: Kids with psych disorders most likely to take dangerous viral challenges

The “choking game” — and other clearly ill-advised and dangerous internet challenges — leave many parents wondering what drives teens to take the bait and participate. Now, a new study suggests that an underlying psychological disorder may be one reason why some kids jump at online dares such as the “Bird Box” challenge, where people walk around blindfolded, and the Tide Pod challenge, daring people to eat laundry detergent. (January 28, 2019) Read the full article here from Brain Health Daily http://bit.ly/2DIWHbD
Post a Comment
Read more

The emerging influential role of microglia in neurology

In her most catchily titled book, The Angel and the Assassin , Donna Jackson Nakazawa highlighed nerve cells which have hitherto been very little acknowledged – microglia . Long ignored as bit players in the big league of the nervous system, Nakazawa colourfully illustrated what many neuroscientists are beginning to realise: the small size of microglia belies their huge influence ; m icroglia are, after all, the defence force of the nervous system, protecting the brain from microbial invaders . In keeping with their small size, their role is to surreptitiously  present the antigens of invading bugs to T cells , the toffs who actually carry out the final hatchet job . It is therefore not surprising that any dysfunction of microglia will come with significant clinical consequences .  By GerryShaw – Own work , CC BY-SA 3.0 , Link The most important clinical fallout of dysfunctional microglia appears to be the emergence of dementia. It is indeed spec...
Post a Comment
Read more