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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Gut injection of α-synuclein fibrils converts endogenous α-synuclein to a pathologic species that spreads to the brain. This leads to features of Parkinson’s disease, and vagotomy and α-synuclein deficiency prevent the neuropathology and neurobehavioral deficits induced by transmitted pathological α-synuclein.

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