Increased free prostate specific antigen serum levels in Alzheimer's disease, correlation with clinical severity

Prostate specific antigen (PSA) is regulated by steroid hormones, such as testosterone, the serum levels of which are altered in patients with Alzheimer's disease (AD).This pilot study compared serum levels of the free (f) PSA in AD and mild cognitive impairment (MCI), and control subjects, and evaluated the relationship between fPSA serum levels and disease severity and neuroimaging data. In addition, in a subgroup of AD patients, we correlated fPSA serum levels with the existing data on serum levels of amyloid-beta (Aβ), and iron-related proteins, including hepcidin and ferritin.

from Journal of the Neurological Sciences https://ift.tt/2UhG00Z