Editors' note: Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline

Using the prospective observational Atherosclerosis Risk in Communities cohort, Rawlings et al. sought to determine an independent association between orthostasis and risk of stroke and dementia. After adjustment for known vascular risk factors and other medical history that are associated with stroke and dementia risk, the investigators found an independent association between orthostatic hypotension (OH) and stroke (hazard ratio [HR] 2.08, 95% confidence interval [CI] 1.65–2.62) and dementia (HR 1.54, 95% CI 1.20–1.97) throughout the 16-year follow-up period.

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