Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites

Gaffield et al. find that sensory stimuli enhance climbing fiber responsiveness, leading to larger Purkinje cell Ca2+ events. This integrative process is unaffected by local neural circuits, indicating the primacy of the inferior olive in instructional signaling.

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