α1ACT Is Essential for Survival and Early Cerebellar Programming in a Critical Neonatal Window

Du et al. detail how a novel transcription factor, α1ACT, orchestrates postnatal cerebellar development, a finding highly relevant to loss-of-function CACNA1A genetic developmental disorders. The role of α1ACT wanes in adulthood, paving the way for its safe suppression to treat gain-of-function mutations.

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