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Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

http://www.ajnr.org/content/40/1/99
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  1. A ThoughtJanuary 26, 2019 at 10:39 PM

    According to study group

    Conclusions
    Our study provides additional information about DGM involvement in patients with MS, showing the presence of alterations of different MR imaging metrics as a possible reflection of neurodegenerative and neuroinflammatory processes in these structures. Furthermore, our results demonstrate the presence of a different behavior of DGM atrophy in MS phenotypes, with subcortical GM volume loss mainly determined by global WM lesion burden in patients with RRMS, while local microstructural damage, along with susceptibility changes, account for the development of the significant DGM atrophy occurring in patients with PMS.

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