Skip to main content

Posts

Autistic People’s Nerve Cells Differ Before Birth

Atypical brain development begins at the very earliest stages of brain organization, at the level of individual neurons. from Neuroscience News https://ift.tt/3lg99n2

Pavlovian bias in Parkinson’s disease: an objective marker of impulsivity that modulates with deep brain stimulation

Congratulations Drs. Janine Lopes, and Michael Okun on the publication of “ Pavlovian bias in Parkinson’s disease: an objective marker of impulsivity that modulates with deep brain stimulation. ”  This article was published in the August edition of Scientific Reports. Abstract Impulsivity is a common symptom in Parkinson’s disease (PD). Adaptive behavior is influenced by prepotent action-reward and inaction-avoid loss Pavlovian biases. We aimed to assess the hypothesis that impulsivity in PD is associated with Pavlovian bias, and to assess whether dopaminergic medications and deep brain stimulation (DBS) influence Pavlovian bias. A PD DBS cohort (N = 37) completed a reward-based Go/No-Go task and bias measures were calculated. This DBS cohort completed the task under three conditions: on-med/pre-DBS, off-med/off-DBS, and on-med/on-DBS. Participants also completed self-reported measures of impulsivity. Dopaminergic medication was associated with lower action-reward bias whil...