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Genes Related to Inflammation and Stress May Help Tailor Treatments for Depression

Gene expression study reveals it is possible to distinguish between those with treatment-resistant depression and those with major depressive disorder who respond to antidepressants based on levels of inflammation and the presence of molecular mechanisms that spark inflammation into action. from Neuroscience News https://ift.tt/3eYwOEf
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Genomic alterations in Turcot syndrome: Insights from whole exome sequencing

Turcot's syndrome (TS) was originally described as familial predisposition to cancer of the large bowel and brain [1], and is a phenotypic variant of Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is caused by germline mutations in one of the DNA mismatch-repair (MMR)-genes MLH1, PMS1, PMS2, MSH2, or MSH6. Identification of HNPCC is based upon clinicopathological features including MMR-deficiency determined by immunohistochemistry or microsatellite instability (MSI)-analysis. Lifetime brain tumor risk in HNPCC is 3%. from Journal of the Neurological Sciences https://ift.tt/3jBqBkS
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Can an EEG Detect COVID-19?

An analysis of EEG data from novel coronavirus patients, published in the French journal Neurophysiologie Clinique , could not find any patterns that could be linked specifically to COVID-19 – but more research like this was deemed necessary. In the early months of the COVID-19 pandemic, EEG technologists were among a group of healthcare workers making the news because they were actually working less while ERs, ICUs, and respiratory care personnel were stretched beyond capacity. Evidence linking the coronavirus to neurological complications – such as change in consciousness, stroke, and encephalopathy – began to slowly build . It was accompanied by an increase in research looking at just how the virus impacts the brain. Professionals working with patients positive for COVID-19 began to notice some neurological problems like confusion, possible seizures, and a slowness to wake from anesthesia. That’s when EEG techs were asked to garb up in full PPE and perform EEGs. ASET- The Neu
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Neurological Complications of COVID-19 Becoming More Clear

Though COVID-19 has most notably affected the respiratory system, case studies with related neurological disease began trickling in soon after the pandemic started. Those reports have continued to grow, including cases of central and peripheral nervous system disorders. The exact injury mechanism, however, has been elusive. A new multidisciplinary study out of the United Kingdom takes one of the deepest dives yet into the many ways COVID-19 wreaks havoc on the nervous system. In early March 2020, it started to become apparent that COVID-19 was linked to the development of certain neurological conditions, including encephalopathy, stroke, and Guillain-Barré Syndrome (GBS). Dr. Elaine Jones “There were a lot of neurologic presentations that ended up being COVID-positive patients,” Dr. Elaine Jones, a neurologist who does telehealth in ERs across the country, told us. “We are still working through that data to see what it was. Some of it, we think, was inflammation of the vessels.
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