NEURO

Author: Edited by Andrew C. Papanicolaou, Timothy P.L. Roberts, and James W. Wheless ISBN: 9780190935689 Binding: Hardcover Publication Date: 30 July 2020 Price: $125.00 from journals https://ift.tt/3135LCr

This randomized clinical trial investigates whether continuous electroencephalogram is associated with reduced mortality compared with routine electroencephalogram. from journals https://ift.tt/3031Fei

This Viewpoint discusses an updated image of Parkinson disease that more accurately reflects the heterogeneity in age at onset, sex, race/ethnicity, and disease experience. from journals https://ift.tt/3f70w9R

Author: Lawrence A. Zeidman ISBN: 9780198728634 Binding: Hardcover Publication Date: 26 July 2020 Price: $50.00 from journals https://ift.tt/3hyBxhx

This cohort study compares the parameters used for prognosis after cardiac arrest with the severity of hypoxic-ischemic encephalopathy shown on autopsy. from journals https://ift.tt/2OWu8wc

This Viewpoint advocates for expanded usage of tenecteplase in patients with stroke as a means of avoiding coronavirus disease 2019 spread and easing potential shortages of alteplase. from journals https://ift.tt/3htCoQx

The hippocampal activity supporting trace fear conditioning has long been mysterious, but a leading hypothesis posits “time-cell”-like sequential patterns. In this issue of Neuron, Ahmed et al. (2020) present new data suggesting that, at least during the first session of learning, a subset of neurons coalesce to selectively encode the task but without expressing reliable sequences. from journals https://ift.tt/2D07HTT

Dipeptide repeat proteins (DPRs) occur via repeat-associated non-AUG (RAN) translation. In this issue of Neuron, McEachin et al. (2020) show that the aggregation-prone poly(GA)-rich chimeric DPRs determine divergent poly(GP) mediated pathology between C9ALS/FTD and SCA36. from journals https://ift.tt/32LnP6W

How circulating signals enter the median eminence to trigger homeostatic hypothalamic responses is not well understood. Jiang et al. describe a neural mechanism that increases endothelial fenestrations and enhances the hypothalamic response to the circulating hormone leptin, suggesting a novel way to regulate brain entry through vascular wall remodeling. from journals https://ift.tt/2OOlXSo

How can fish see tiny underwater prey invisible to human eyes? In this issue of Neuron, Yoshimatsu et al. (2020) show that ultraviolet light and a rich set of fine-tuned anatomical and neural specializations originating in ultraviolet-sensitive cones underlie high-resolution prey-capture behavior in larval zebrafish. from journals https://ift.tt/2WHSLkj

One hallmark of the mature visual cortex is binocularly matched orientation maps. In this issue of Neuron, Chang et al. (2020) show that three different maps exist at vision onset and that binocular visual experience aligns them into a single unified representation. from journals https://ift.tt/2E9NZG5

(Neuron 103, 559–562;August 21, 2019) from journals https://ift.tt/3eSJdcw

This meta-analysis seeks to determine if an episode of delirium is an independent risk factor for long-term cognitive decline. from journals https://ift.tt/3iVaApI

The association between sleep and overall health and well-being has long been of interest to physicians, researchers, and the general public. At the highest level, a simple U-shaped association between total sleep time and mortality has been described from as early as 1964. Those who sleep approximately 7 hours are at the lowest point in the curve, with the lowest mortality risk. Mortality increases incrementally as one moves in either direction on the curve, with a marked rise for those sleeping less than 4 hours or more than 10 hours. This association holds true for both sexes and across races/ethnicities and continents. from journals https://ift.tt/3iC7l6w

This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older. from journals https://ift.tt/3iC7qqQ

This cross-sectional study investigates the potential of novel tau radiotracer 18F-PI-2620 as a biomarker in patients with clinically diagnosed progressive supranuclear palsy. from journals https://ift.tt/2C7izz3

Krabbe disease is characterized by GALC deficiency and Schwann cell impairment. In a recent issue of Neuron, Weinstock et al. (2020) show that hematopoietic stem cell transplantation, an established therapy, improves pathology in a mouse model through an unexpected GALC-dependent mechanism, i.e., by providing functional macrophages capable of phagocytosis, rather than by supplying GALC for Schwann cell function. from journals https://ift.tt/31ZPFM6

Loss-of-function variants in the PYRC2 gene cause hypomyelinating leukodystrophy 10 (HLD10), but the associated pathogenic mechanisms are unknown. In this issue of Neuron, Escande-Beillard et al. (2020) reveal that PYRC2 is a key enzyme for proper brain development and a regulator of glycine homeostasis, uncovering hyperglycinemia as a driver of HLD10 pathogenesis. from journals https://ift.tt/2Dq30mV

In this issue of Neuron, Orr et al. (2020) identify an evolutionarily conserved mechanism of presynaptic homeostatic plasticity induced by ALS-like motor neuron degeneration, which maintains excitatory potentials until a threshold of synaptic loss is reached. Past this tipping point, disease onset progresses rapidly. from journals https://ift.tt/3gD5wnT

C1ql3 protein and its receptor Bai3 are involved in synaptic organization and function. In this issue of Neuron, Wang et al. (2020) report that both are essential for synaptic function between the anterior olfactory nucleus and the olfactory bulb and for the generation, but not recall, of associative olfactory memories determining food preference in mice. from journals https://ift.tt/31UZ87k