NEURO

This nonrandomized controlled trial analyzes safety, biological, and functional outcomes associated with the infusion of rAAVrh74.MHCK7.micro-dystrophin gene transfer in a small group of patients with Duchenne muscular dystrophy. from journals https://ift.tt/30Lu0Xh

This randomized clinical trial assesses the effect of hookworm treatment on magnetic resonance imaging activity and T regulatory cells in British patients with relapsing multiple sclerosis. from journals https://ift.tt/3fpbisM

This cohort study examines data from original and offspring participants in the Framingham Heart Study to assess the incidence of intracerebral hemorrhage, incidence rates stratified by deep and lobar brain locations, and location-specific risk factors between 1948 and 2016. from journals https://ift.tt/30kBXCP

This Viewpoint discusses the importance of developing vaccines even after an epidemic ends because it may help with vaccine development for a future viruses in the same family. from journals https://ift.tt/30kXECx

This secondary analysis of data from 2 randomized clinical trials examines the relative contribution of relapse-associated vs relapse-independent progression to overall confirmed disability accumulation in patients with multiple sclerosis and assesses respective baseline prognostic factors and outcomes of the 2 treatments. from journals https://ift.tt/3eWzBho

This diagnostic study assesses the sensitivity and specificity of diffusion magnetic resonance imaging with a new criterion of at least 1 positive brain region for the diagnosis of sporadic Creutzfeldt-Jakob disease. from journals https://ift.tt/2Mgz2Tm

In this issue of Neuron, Fernandes et al. (2020) compare intra-gastric sugar and non-caloric sweetener to investigate how post-ingestive effects can be reinforcing, revealing a role for the hepatic vagus nerve in transforming sugar sensing by the gut into behavioral reinforcement via midbrain dopamine neuron responses. from journals https://ift.tt/2XwEBnf

Mutations in TANK-binding kinase 1 (TBK1) are linked to ALS-FTD. In this issue of Neuron, Gerbino et al. (2020) show how missense mutations in the kinase domain of TBK1 differentially affect disease onset and progression in an ALS mouse model. from journals https://ift.tt/2Ms4EW4

Enrichment of sodium channels at nodes of Ranvier, a hallmark of myelinated axons, underlies effective saltatory conduction. In this issue of Neuron, Eshed-Eisenbach et al. (2020) demonstrate that proteolysis of gliomedin, which drives initial channel clustering, provides a novel mechanism to ensure fidelity of channel localization to nodes. from journals https://ift.tt/2ADXP1i

Detection of NaCl by the gustatory system is fundamental for salt intake and tissue homeostasis. Yet, signal transduction mechanisms for salty taste have remained obscure. In this issue of Neuron, Nomura et al. (2020) report that the epithelial sodium channel ENaC, which serves as the salty receptor, is co-expressed with the voltage-activated ATP release channel CALHM1/3 in a subset of taste cells and that these cells mediate amiloride-sensitive salty taste. from journals https://ift.tt/3gPcFT5

In this issue of Neuron, Paricio-Montesinos et al. (2020) unveil the essential cellular elements for warm temperature detection in mice. Surprisingly, the silencing of spontaneously firing, unmyelinated, polymodal sensory afferents harboring cold-activated TRPM8 channels is the key neural mechanism. from journals https://ift.tt/3052Udm

Ketamine exerts rapid antidepressant action in depressed and treatment-resistant depressed patients within hours. At the same time, ketamine elicits a unique form of functional synaptic plasticity that shares several attributes and molecular mechanisms with well-characterized forms of homeostatic synaptic scaling. Lithium is a widely used mood stabilizer also proposed to act via synaptic scaling for its antimanic effects. Several studies to date have identified specific forms of homeostatic synaptic plasticity that are elicited by these drugs used to treat neuropsychiatric disorders. In the last two decades, extensive work on homeostatic synaptic plasticity mechanisms have shown that they diverge from classical synaptic plasticity mechanisms that process and store information and thus present a novel avenue for synaptic regulation with limited direct interference with cognitive processes. In this review, we discuss the intersection of the findings from neuropsychiatric treatments and h

This comparative effectiveness study describes the analytical strategy, methods, and results of a target trial emulation examining cohorts of US veterans with carotid stenosis. from journals https://ift.tt/3eQRONB

Author: Michel Ferrari, Andrew Charles, David Dodick, Fumihiko Sakai, and Joost Haan ISBN: 9780198724322 Binding: Hardcover Publication Date: 01 June 2020 Price: $185.00 from journals https://ift.tt/3dnJww5

This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complications of coronavirus disease 2019. from journals https://ift.tt/3gAs6hV

This case report describes a 25-year-old female radiographer with no significant medical history who had been working in a coronavirus disease 2019 (COVID-19) ward who presented with a mild dry cough that lasted for 1 day, followed by persistent severe anosmia and dysgeusia. from journals https://ift.tt/3gtheSO

Intracranial artery stenosis (ICAS) is a leading cause of stroke worldwide. It is estimated to account for 10% of ischemic strokes in the US and perhaps up to 50% of strokes in Asia. Despite its frequency and role in stroke-related morbidity and mortality, ICAS has received less attention compared with extracranial atherosclerotic disease. In the past 15 years, clinical trials have refined the treatment approach for patients with recent stroke or transient ischemic attack (TIA) and ICAS. However, less information is available pertaining to asymptomatic ICAS. from journals https://ift.tt/36vQ4pW

This phase 2 randomized clinical trial evaluates the safety, tolerability, and efficacy of viltolarsen in boys with Duchenne muscular dystrophy amenable to exon 53 skipping from journals https://ift.tt/3gqTDlW

This cohort study examines the age-specific prevalence and prognosis of asymptomatic intracranial stenosis in British patients with transient ischemic attack and minor stroke. from journals https://ift.tt/3gxvaLR

This randomized clinical trial compares 3 treatment strategies among patients with medication overuse headache in Denmark. from journals https://ift.tt/3emPT2L