Outside of the vaccine debate, few medical topics can get people riled up like Lyme disease. In fact, the term “Lyme wars” is often used to describe the debate about the diagnosis and treatment of this tick-borne disease. The bad news is that this debate probably isn’t going away anytime soon. The good news is that The American Academy of Neurology, Infectious Diseases Society of America, and American College of Rheumatology have introduced new draft guidelines in an effort to reduce some of this conflict and make treatment decisions easier for those on the front lines. Prevention of Lyme Disease Beginning with prevention, the new guidelines address how to handle a “high-risk” tick bite, which must: Be from an Ixodes tick Occur in a highly endemic area Come from an engorged tick attached for 36 hours or more. If these three requirements are met, a single dose of oral doxycycline should be administered within the first 72 hours after tick removal. If the bite does not satisfy