NEURO

Non-pharmacological interventions such as physiotherapy are recognized as important elements in the overall clinical management of motor impairments in PD, but evidence of physiotherapy in advanced disease stages is sparse. A recent trial found positive effects of multimodal balance training in people with mild to moderate PD, with greater and more sustained effects when rhythmical auditory stimuli were added. It is unclear whether such multimodal balance training is also effective in people with advanced PD (Hoehn & Yahr stage 4). from Journal of the Neurological Sciences https://ift.tt/33JOmSs

Neurological symptoms in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are commen [1]. SARS-CoV-2-RNA was detected by reverse-transcriptase–polymerase-chain-reaction (RT-PCR) in very few cases in cerebrospinal fluid (CSF) [2] as well as virus particles in autopsy brain samples in single cases [3]. This has prompted an ongoing controversy whether neurological symptoms are caused by viral infection of the CNS or via other mechanisms. from Journal of the Neurological Sciences https://ift.tt/2FbmRad

Myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disorders (MOGAD) manifest with attacks of optic neuritis(ON), transverse myelitis(TM), encephalitis, or combinations [1]. The acute episodes are generally characterized by severe neurologic dysfunction (e.g., severe vision loss, paraplegia, encephalopathy) accompanied by large T2-lesions (usually >2/3 of the optic nerve, longitudinal involvement of spinal cord or multifocal brain involvement) on magnetic resonance imaging (MRI) [2,3]. from Journal of the Neurological Sciences https://ift.tt/3iprbkn

To the Editor, from Journal of the Neurological Sciences https://ift.tt/3ku5hyf

The coronavirus disease 2019 (Covid-19) pandemic has led to challenges in provision of care, clinical assessment and communication with families. The unique considerations associated with evaluation of catastrophic brain injury and death by neurologic criteria in patients with Covid-19 infection have not been examined. from Journal of the Neurological Sciences https://ift.tt/3komDwr

Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. from Journal of the Neurological Sciences https://ift.tt/2Dk8gsx

Personalized medicine (PM) aims to optimize patient management, taking into account the individual traits of each patient. The main purpose of PM is to obtain the best response, improving health care and lowering costs. Extending traditional approaches, PM introduces novel patient-specific paradigms from diagnosis to treatment, with greater precision. In neuro-oncology, the concept of PM is well established. Indeed, every neurosurgical intervention for brain tumors has always been highly personalized. from Journal of the Neurological Sciences https://ift.tt/2XwQpWc

Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal dominant inherited diseases that share the degeneration of the cerebellum and its connections as their main feature. We performed a detailed description of the natural history of the main SCAs, focusing on epidemiology, progression, haplotype analysis and its correlation with founder effect, and perspective of future treatments. References for this review were identified by an in-depth literature search on PubMed and selected on the basis of relevance to the topic and on the authors' judgment. from Journal of the Neurological Sciences https://ift.tt/3khcgdO

Dear Editor: from Journal of the Neurological Sciences https://ift.tt/2DDh5gA

This article presents an overview of the most important points a neurologist must remember when dealing with a patient complaining of diplopia. Patients with monocular diplopia and those with full ocular motility and comitant misalignment should be referred to an ophthalmologist and do not require further testing. Patients with recent onset of binocular diplopia who have associated “brainstem” symptoms should have an urgent brain MRI. All patients with 3rd cranial nerve palsy require urgent brain CTA to rule out compressive aneurysmal lesion. from Journal of the Neurological Sciences https://ift.tt/2DE2QYQ

Amyotrophic Lateral Sclerosis (ALS) is a fast-progressive neurodegenerative disease leading to progressive physical immobility with usually normal or mild cognitive and/or behavioural involvement. Many patients are relatively young, instructed, sensitive to new technologies, and professionally active when developing the first symptoms. Older patients usually require more time, encouragement, reinforcement and a closer support but, nevertheless, selecting user-friendly devices, provided earlier in the course of the disease, and engaging motivated carers may overcome many technological barriers. from Journal of the Neurological Sciences https://ift.tt/3gy7vdC

To identify Parkinson's disease with mild cognitive impairment (PD-MCI) through surface-based morphometry (SBM) based machine learning model. from Journal of the Neurological Sciences https://ift.tt/2EIJouF

COVID-19 pandemic has resulted in an unprecedented increased usage of Personal protective equipment (PPE) by healthcare-workers. PPE usage causes headache in majority of users. We evaluated changes in cerebral hemodynamics among healthcare-workers using PPE. from Journal of the Neurological Sciences https://ift.tt/39XijPZ

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) which commonly leads to disability. We reviewed articles on MS from Pakistan using PubMed, Google Scholar and Pak Medinet to present different aspects of the disease and the status of disease modifying treatments in Pakistan and South Asia. MS is not as uncommon in Pakistan as it has been previously thought to be. Estimated prevalence of MS in Pakistan may be 10 per 100,000 population. Data suggests that most features of MS found in Pakistan are similar to those found in the West. from Journal of the Neurological Sciences https://ift.tt/3jVepf4

The practice of platelet transfusion to mitigate the deleterious effects of antiplatelet agents on spontaneous intracerebral hemorrhage (ICH) remains common. However, the effect of antiplatelet agents on patients with ICH is still controversial and transfusing platelets is not without risk. We performed a meta-analysis in order to determine the effect of platelet transfusion on antiplatelet agent associated ICH. from Journal of the Neurological Sciences https://ift.tt/33dnHNJ

We previously reported on 40 patients with Guillain-Barre syndrome (GBS) identified 1999–2005 at our center, and showed a higher proportion with an axonal pattern than in Europe and North America. from Journal of the Neurological Sciences https://ift.tt/33eb1G4

Homonymous hemimacular thinning of the retinal ganglion cell-inner plexiform layer (GCIPL) on optical coherence tomography (OCT) in the absence of significant visual field defects may be identified in the workup of patients with visual complaints, but the causes of this finding remain unknown. We retrospectively reviewed 1425 consecutive patients referred for neuro-ophthalmic assessment who had high quality OCT scans and reliable Humphrey 24–2 SITA-Fast testing. A total of 7 patients, 3 females and 4 males, with a mean age of 39.4 ± 10.5 years that had homonymous thinning of the OCT macular-GCIPL without significant visual field defects were included in the study. from Journal of the Neurological Sciences https://ift.tt/30g1IUp

Here, we report a patient with COVID-19 with delayed onset multi-vessel cerebral infarcts and systemic pro-thrombotic state and coagulopathy manifesting as acute limb ischemia and pulmonary embolism to highlight the importance of vigilant monitoring for neurologic impairment and coagulopathy in patients with severe cases of COVID-19 infection. In December 2019, a cluster of pneumonia cases emerged in Wuhan, Hubei Province; later identified as a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19). from Journal of the Neurological Sciences https://ift.tt/3g78fGm

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease with characteristic of progressive general muscle weakness and atrophy. ALS is still lack of efficient treatment and laboratory biomarkers. In this study, we longitudinally examined ALS patients' peripheral blood to search potential biomarkers.18 ALS patients aged between 20 and 65 years were recruited in a clinical trial and longitudinal plasma samples were obtained and analyzed at baseline, 1, 3, 6 and 12 months follow up. from Journal of the Neurological Sciences https://ift.tt/335FsOH

ew drugs were confirmed to be effective in the treatments of neurological dysfunction caused by acute intracerebral hemorrhage (ICH). The present prospective clinical trial aims to evaluate the effect of mouse nerve growth factor (mNGF) on neurological function in patients with acute ICH. from Journal of the Neurological Sciences https://ift.tt/30e5rSx